Chemical Composition of Pulicaria undulata (L.) Methanolic Extract and Its Potential Antioxidant and Cytotoxic | ||
| Egyptian Journal of Chemistry | ||
| Articles in Press, Accepted Manuscript, Available Online from 26 August 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2025.381851.11710 | ||
| Authors | ||
| Awf A. Al-Rubaye; El‐Sayed F. El‐Halawany; Ashraf A. Elsayed; Yasser A. El-Amier | ||
| Botany Department, Faculty of Science, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| Natural products play a vital role in the development, design, and discovery of new medications, while also serving as a key source of drugs and biologically active compounds. This study investigates the chemical composition, antioxidant, and cytotoxic properties of the methanolic extract of Pulicaria undulata (L.). Utilizing GC-MS analysis, we identified various bioactive compounds, including fatty acids and terpenoids, contributing to its therapeutic potential. Antioxidant activity was evaluated using DPPH and ABTS assays, revealing concentration-dependent scavenging effects, with IC₅₀ values of 38.46 mg/mL (DPPH) and 33.51 mg/mL (ABTS). Additionally, cytotoxic effects were assessed on human tumor cell lines (HePG-2, MCF-7, PC3), demonstrating selective cytotoxicity, particularly against HePG-2 cells (IC₅₀: 36.59 µg/mL) while sparing normal WI-38 fibroblasts (IC₅₀: 100 µg/mL). These results emphasize the potential of Pulicaria undulata as a valuable source of antioxidants and anticancer compounds, encouraging further investigation for therapeutic uses. | ||
| Keywords | ||
| Pulicaria undulata; GC-MS; bioactive component; DPPH, Anticancer | ||
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