Evaluation of the role of ELISA in confirmation of Schistosoma haematobium infection in bilharzial bladder cystitis and bilharzial bladder cancer patients. | ||||
| Sohag Medical Journal | ||||
| Volume 29, Issue 3., 2025, Page 1-7 PDF (1.12 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/smj.2025.403156.1589 | ||||
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| Authors | ||||
Esraa Omar Ali1; Mohamed Mahmoud ali2; Hanaa Ahmed Alhady1; Atef Galal Abdel-wahab3; Hesham Ebrahim Osman   1
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| 1medical parasitology-faculty of medicine-sohag university-sohag | ||||
| 2Department of Urology, Faculty of Medicine, Azhar Assiut University, Assiut, Egypt | ||||
| 3Department of Urology, Faculty of Medicine, Sohage University, Sohag, Egypt | ||||
| Abstract | ||||
| Background: The Human Schistosoma haematobium (Sh) antibody is an IgG that can be used in the diagnosis of Sh infection complicated by bladder cancer (BC) Aim: To evaluate the role of ELISA in the confirmation of Schistosoma haematobium infection in bilharzial bladder cystitis and bilharzial bladder cancer patients Patients and Methods: This case-control study enrolled 60 cases. 17 to 70 years old, males and females, had urinary manifestations, were grouped into three equal groups. Group I: Twenty patients with bilharzial BC. Group II: Twenty patients with chronic bilharzial cystitis. Group III: control: Twenty Healthy cases, microscopic urine examination, and an ELISA test for blood samples were done for all groups. Results: Age ranged from 17 to 74 years. The Ages were higher in the bilharzial BC group than in the chronic bilharziasis group (P=0.048). Sex was insignificant among groups. Rural residence was found in all groups. By microscopy, the presence of ova in the urine sample was positive in 14 (70%) in the chronic bilharziasis group, 5 (25%) in the bilharzial bladder cancer group, and was negative in the control group (P value<0.001). Anti-bilharzial AB was positive in 15 (75%) in the chronic bilharziasis group, 17 (85%) in the BC group, and was negative in the control group (P value<0.001). Anti-bilharzial AB can predict bilharzial disease (P value<0.001) with 84.2% sensitivity, 100% specificity, 100% PPV, 76.9% NPV, and 89.7% Accuracy. Conclusions: Anti-bilharzial AB can be used in confirmation of Schistosomiasis infection in bilharzial bladder cystitis and bilharzial bladder cancer patients. | ||||
| Keywords | ||||
| ELISA; Schistosoma haematobium; Urine; Bladder Cancer | ||||
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