Electrochemical and Supercapacitive Properties of 4-((2-(5-((4-nitrophenyl)azo)-4-phenylthiazol-2-yl)hydrazineylidene)methyl)-benzoic acid (NTBA): Modified Electrodes for Sensing and Biomedical Applications | ||||
| Egyptian Journal of Chemistry | ||||
| Articles in Press, Accepted Manuscript, Available Online from 26 August 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2025.381843.11708 | ||||
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| Authors | ||||
| Ahmed M. Sarhan1; Ehab Abdel-Latif1; Esam A. Gomaa1; Farid E. El-Dossiky2; Amr M. Abdelghany3, 4; Safa A. Badawy1 | ||||
| 1Chemistry Department, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt. | ||||
| 2Chemistry Department, Faculty of Science, Port Said University, Egypt. | ||||
| 3Spectroscopy Department, Physics Research Institute, National Research Centre, 33 ElBehouth St., Dokki, 12311, Giza, Egypt | ||||
| 4Basic Science Department, Horus university, International Coastal Road, New Damietta, Egypt | ||||
| Abstract | ||||
| A novel thiazole derivative, 4-((2-(5-((4-nitrophenyl)azo)-4-phenylthiazol-2-yl)hydrazineylidene)methyl)-benzoic acid (NTBA), was synthesized with an 89% yield and characterized using IR, UV-Vis, ¹H NMR, and ¹³C NMR spectroscopy. The compound exhibited a highly conjugated structure, as confirmed by spectroscopic analyses. Electrochemical studies revealed that NTBA-modified indium tin oxide (ITO) electrodes, enhanced with carboxymethyl cellulose (CMC), demonstrated superior supercapacitive performance, with a specific capacitance of 0.0916 F/g, significantly higher than that of conventional glassy carbon electrodes (0.05295 F/g). Cyclic voltammetry indicated selective interactions with Cu²⁺, Mn²⁺, and MnO₄⁻ ions, following diffusion-controlled mechanisms. Antioxidant assays (DPPH and ABTS) showed NTBA's potent radical scavenging activity, with IC₅₀ values of 29.26 mg/L and 36.94 mg/L, respectively, highlighting its potential for biomedical applications. Molecular docking studies using the Molecular Operating Environment (MOE) software identified two binding poses of NTBA with the viral protein 7JWY (SARS-CoV-2 target), exhibiting free binding energies of -5.33 kcal/mol and -5.23 kcal/mol. Key interactions involved residues Lys129, Asn125, Val171 (Pose 1) and Lys529, Asn331, Gln580, Arg328 (Pose 2), suggesting potential antiviral properties. This study underscores NTBA's multifunctionality as a promising material for energy storage, environmental sensing, and biomedical applications, bridging advancements in electrochemistry, supercapacitor technology, and therapeutic research. | ||||
| Keywords | ||||
| Thiazole sensitizer; Cyclic Voltammetry; Super capacity; Antioxidant; COVID -19 | ||||
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