Assessment of some Biochemical Markers as risk factors in Egyptian children affected with Acute Lymphoblastic Leukemia
Radwan, R., El-kholy, W., Elsaid, A., Darwish, A. (2023). Assessment of some Biochemical Markers as risk factors in Egyptian children affected with Acute Lymphoblastic Leukemia. EKB Journal Management System, 65(4), 56-66. doi: 10.21608/mjb.2023.449568
Roqaia E. Radwan; Wafaa M. El-kholy; Afaf M. Elsaid; Ahmad Darwish. "Assessment of some Biochemical Markers as risk factors in Egyptian children affected with Acute Lymphoblastic Leukemia". EKB Journal Management System, 65, 4, 2023, 56-66. doi: 10.21608/mjb.2023.449568
Radwan, R., El-kholy, W., Elsaid, A., Darwish, A. (2023). 'Assessment of some Biochemical Markers as risk factors in Egyptian children affected with Acute Lymphoblastic Leukemia', EKB Journal Management System, 65(4), pp. 56-66. doi: 10.21608/mjb.2023.449568
Radwan, R., El-kholy, W., Elsaid, A., Darwish, A. Assessment of some Biochemical Markers as risk factors in Egyptian children affected with Acute Lymphoblastic Leukemia. EKB Journal Management System, 2023; 65(4): 56-66. doi: 10.21608/mjb.2023.449568

Assessment of some Biochemical Markers as risk factors in Egyptian children affected with Acute Lymphoblastic Leukemia

Mansoura Journal of Biology
Volume 65, Issue 4, December 2023, Page 56-66  XML PDF (895.2 K)
Document Type: Original Article
DOI: 10.21608/mjb.2023.449568
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Authors
Roqaia E. Radwan* 1; Wafaa M. El-kholy1; Afaf M. Elsaid2; Ahmad Darwish3
1Physiology Section, Zoology department, Faculty of Science, Mansoura University, Egypt
2Children Hospital, Mansoura University
3Hematology, Oncology and Bone Marrow Unit, Pediatric Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Abstract
Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. The oncogenes that control the production of ROS and the expression of antioxidants have the ability to influence the apoptosis pathway and control the progression of leukemia. This research investigated the inter-relationship between antioxidant markers, oxidative stress, and some biochemical markers in acute lymphoblastic leukemia Egyptian children. Antioxidants such as superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). In addition to oxidative stress markers such as malondialdehyde (MDA). Furthermore, electrolytes such as (Na, K, Cl, Ca, Mg, and P). Moreover, liver profile, kidney profile and Glucose in acute lymphoblastic leukemia Egyptian population. This study produced 100 children diagnosed with acute lymphoblastic leukemia (ALL) (mean age, 9.5 years) compared to 100 healthy controls (mean age, 8.5 years). Significant increases were obtained in Na and K, MDA, and GSH levels in ALL groups compared to the control group. While, we found a significant decrease was found in serum SOD and CAT in ALL groups compared to the control group (p<0.001). Conclusion: There is a strong association between electrolytes (Na and K), antioxidants (SOD, CAT, and GSH), and oxidative stress (MDA) with acute lymphoblastic leukemia. Which means, these parameters could be risk factors in ALL.
Keywords
ALL; Biochemical markers; Electrolytes; Oxidative stress; Antioxidants
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