Cardiovascular Damage Index Score and Disease Activity among Patients with Systemic Lupus Erythematosus | ||||
| Zagazig University Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 26 August 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2025.408035.4080 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Noha A. Abdelsalam   1; Reham Abd Elkhalek2; Shaimaa Wageeh 3; Samar A. Abdelsalam 4; Wafaa k. Makram 5
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| 1Lecturer in Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig City, Egypt | ||||
| 2Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. | ||||
| 3Cardiology Department, Faculty of Medicine, Zagazig University, 44519, Zagazig, Egypt. | ||||
| 4Family Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. | ||||
| 5assistant professor of rheumatology and rehabilitation ,faculty of medicine ,zagazig university | ||||
| Abstract | ||||
| Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can harm multiple organs, including cardiovascular system. Disease activity is crucial in determining risk of organ damage. This research aimed to assess Cardiovascular Damage (CV) Index score in SLE and its association with disease parameters, including disease activity. Methods: A cross-sectional study involved 198 SLE patients at rheumatology clinics, Zagazig University Hospitals. Patients were divided into two groups based on SLE Disease Activity Index 2000 (SLEDAI-2K). Patients’ clinic-demographic, laboratory, and echocardiographic data were recorded. Cardiovascular damage index was detected according to cardiac domain of Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index (SDI). Multivariable regression analysis was used to identify potential predictors of CV damage. Results: About (16.7%) of included SLE patients had CV damage. Statistically significant differences were detected between Group I (SLEDAI-2K ≥6) versus Group II (SLEDAI-2K ˂6) regarding left ventricular systolic dysfunction and diastolic dysfunction and pericardial effusion (65.3±5.68 vs 66.9±4.65), (5.40±1.78 vs 4.91±1.57), and (7.1% vs 0.00%), respectively. A significant positive correlation was observed between CV damage index and SLEDAI-2K (r=0.159, P=0.025*). CV damage significantly associated with SLEDAI-2K ≥ 6, smoking, dyslipidemia, pyuria, and hematuria. SLEDAI-2K ≥ 6, smoking, and dyslipidemia were independent predictors for CV damage in SLE. Conclusion: CV damage is detected in (16.7%) of lupus patients. It has a significant positive correlation with disease activity. SLEDAI-2K ≥ 6, smoking, and dyslipidemia are important contributors for developing CV damage in SLE. So, screening all SLE patients with echocardiography is important. | ||||
| Keywords | ||||
| Systemic lupus erythematosus; SLEDAI-2K; Cardiovascular system; Cardiovascular Damage Index; Echocardiography | ||||
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