Comparative Study of Biocompatibility and Toxicity of Chemical and Green Synthesized Silver Nanoparticles | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 13, December 2025, Pages 1111-1134 PDF (6.19 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2025.397161.11952 | ||
| Authors | ||
| Heba Badoa Ibrahim1; Emam Abdelmobdy Abdelrahim2; Mohamed A. Ali* 3 | ||
| 1Biochemistry Department, Faculty of Agriculture, Cairo University, Giza, Egypt. | ||
| 2Biochemistry Department, Faculty of Agriculture, Cairo University, P. Box 12613, Gamma St, Giza, Egypt | ||
| 3Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza, Egypt | ||
| Abstract | ||
| Silver nanoparticles (AgNPs) can be utilized in abroad fascinating biomedical, industrial, and agricultural applications, so they are in increasing demand. However, the ability of AgNPs to accumulate in the human body may cause side effects on various organs. Pomegranate peel extract (PPE) showed biological activity as a protective agent against hepatic and renal diseases. The present study aimed to biosynthesize AgNPs using PEE (PPE-AgNPs) compared to starch (ST-AgNPs), PPE/ST-AgNPs, and chemical synthesis nanoparticles NaBH4-AgNPs to study the physicochemical characteristics of NPs, determine the antioxidant activity and evaluate their biochemical toxicity in vivo. Different synthesized AgNPs were characterized by Ultraviolet-visible (UV-VIS) spectrophotometer, Fourier transform infrared (FTIR), ZetaSizer, and transmission electron microscope (TEM). Fifty five male albino rats were divided into 11 groups (5 rats/group) to examine the toxicity of the prepared nanoparticles. Some hematological, biochemical parameters and apoptotic markers were evaluated. The findings revealed that injected AgNPs caused toxicity in both liver and kidney, as shown in the activity of the liver enzymes and kidney function. Treatment with PEE biosynthesized AgNPs injection ameliorated the harmful in hematological, biochemical parameters and liver homogenate genotoxicity induced by AgNPs toxicity, which was observed histopathologically. These results concluded that natural products and their NPs biosynthesis strategies can be exploited as a green chemistry approach, one-step, cost-effective, and eco-friendly for producing stable AgNPs on a large scale that have the potential to alleviate the alternation in the hematology, biochemical parameters and genotoxicity induced by AgNPs toxicity. This approach supports the dual purpose of natural product management. | ||
| Keywords | ||
| Genotoxicity; Green synthesis; Kidney function; Liver function; Nanoparticles toxicity; Pomegranate; Silver nanoparticles | ||
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