Evaluation of the protective effects of passion fruit (Passiflora edulis) against cisplatin-induced neurotoxicity in rats | ||||
| Biological and Biomedical Journal | ||||
| Volume 3, Issue 2, July 2025, Page 168-190 PDF (432.22 K) | ||||
| Document Type: Research Articles | ||||
| DOI: 10.21608/bbj.2025.399047.1114 | ||||
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| Authors | ||||
Elsayed Elbadrawy  ; Hala Elkewawy; Dina Adel
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| Nutrition and Food Science, Home Economics Department, Faculty of Specific Education, Mansoura University, Egypt | ||||
| Abstract | ||||
| Neurotoxicity is a significant side effect of chemotherapy. This study evaluated the nutritional benefits and protective effects of passion fruit against cisplatin-induced neurotoxicity in rats. A total of 30 rats were involved in the experiment. Six of these rats served as a negative control group. The remaining rats were injected intraperitoneally (i.p.) with cisplatin (2.3 mg/kg) for five consecutive days. Among the four neurotoxic groups, one served as a positive control, while the others received different forms of passion fruit: one group was administered passion fruit juice (PFJ) orally via a stomach tube, another received passion fruit peel powder (PFP), and the last group received a combination of PFJ and PFP for 45 days. Blood samples were collected, and the rats’ brains were isolated to examine various parameters, including antioxidants, anti-inflammatory markers, neurotransmitters, and some hormones. The results indicated that the treated groups had lower levels of malondialdehyde, nitric oxide, and β-amyloid in their brains. Additionally, they showed increases in total antioxidant capacity and higher levels of serotonin, dopamine, and acetylcholinesterase compared to the positive control group. Furthermore, serum levels of C-reactive protein, tumor necrosis factor-alpha, and cyclooxygenase-2 significantly decreased in the treated groups. Histopathological analysis revealed fewer inflammatory cells and normal nerve fibers in the treated rats compared to the positive control group. The study recommends using a combination of passion fruit pulp and peel powder to help mitigate the neurotoxic effects associated with cisplatin, highlighting the potential benefits of passion fruit in reducing the side effects of chemotherapy. | ||||
| Keywords | ||||
| Antioxidants; Anti-inflammatory; Histopathology; Passion fruit; Rats | ||||
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