Analysis of coagulation indices and blood components in severe symptomatic and asymptomatic COVID-19 patients | ||
| Microbes and Infectious Diseases | ||
| Articles in Press, Accepted Manuscript, Available Online from 26 August 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2025.404864.3025 | ||
| Authors | ||
| Zainab Sabah Hassab1; Saadia O. Mohammed2; Nagham Saadi Mohammed* 3; Istabraq fouad ali1; Aya A. Saleem4 | ||
| 1Osol AL-Elm University College, Baghdad, Iraq | ||
| 2AL-Esraa University, Baghdad, Iraq | ||
| 3Department of Pharmacology and Toxicology. College of Pharmacy, Mustansiriyah University, Baghdad, Iraq | ||
| 4College of science for women, University of Baghdad, Iraq | ||
| Abstract | ||
| Background: COVID-19 causes a variety of symptoms, range from those who a symptomatic to those who are really sick and need critical care. There is mounting evidence linking COVID-19 infection to anomalies of the coagulation system and alterations in blood components in various clinical cases. Objectives: This study was designed to understand how these physiological changes may help predict the prognosis of COVID-19 with severe and asymptomatic, to improve treatment approaches. Methods: 450 people who were suspected of having SARS-CoV-2 were enlisted from five health centers in Baghdad, Iraq, between 20 January and 20 April, 2021. Participants were enrolled in the Panbio™ rapid testing and qRT-PCR testing, which confirmed the infection in 350 individuals, including 200 severe cases and 150 asymptomatic cases; another 100 individuals were healthy. Coagulation marker tests included the D-dimer testing by ELFA technology, INR, PTT, Ferritin and blood components. Results: The study results indicate significant elevations in D-dimer, ferritin, and Hb concentrations among individuals with COVID-19, particularly in severe cases (P<0.001). Minor changes in these parameters were also observed in patients asymptomatic in INR (P<0.01) and APTT (P<0.002) levels than controls. Furthermore, the disease's severity was linked to elevated D-dimer (P<0.001) and hemoglobin abnormalities (P<0.001) than asymptomatic. While, PTT (P<0.05), ferritin (P<0.01) have risen amongst those asymptomatic than in severe cases. Conclusion: These results revealed to higher risk of thrombosis occurrences is linked to COVID-19, particularly in severe symptom cases. | ||
| Keywords | ||
| COVID-19; coagulation induces; blood components; symptoms | ||
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