Synergetic Action of Dietary Nucleotides and Phytobiotics as Entero-Hepatic Tonic, Immune Modulators, and Growth Promoters in Broiler Chickens | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 71, Issue 1, 2025, Page 84-97 PDF (1.24 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/vmjg.2025.406300.1049 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mustafa Bastamy1; Nasser Khedr2; Ismail Raheel3; Ahmed Elbestawy4; Mervat Abdel-Latif5; Ahmed Orabi  6
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| 1Department of Poultry Diseases, Faculty of Veterinary Medicine, Cairo University | ||||
| 2Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Benha University | ||||
| 3Department of Bacteriology, Mycology and Immunology, Faculty of Veterinary Medicine, Beni-Suef University | ||||
| 4Department of Bird and Rabbit Diseases, Faculty of Veterinary Medicine, Menoufia University | ||||
| 5Department of Nutrition and Veterinary Clinical Nutrition, Faculty of Veterinary Medicine, Damanhour University | ||||
| 6Department of Microbiology, Faculty of Veterinary Medicine, Cairo University | ||||
| Abstract | ||||
| The global poultry production industry is currently facing significant challenges due to the complete or gradual removal of in-feed antibiotics. One of the most impactful diseases under these conditions is necrotic enteritis (NE), which causes considerable economic losses by compromising intestinal wall permeability and liver health in broiler chickens. The present study investigates the efficiency of dietary nucleotides and phytobiotics feed supplementation on broiler intestinal to alleviate (NE and their effects on gut, liver, growth performance, and immunity parameters. Four groups (Gs) of broiler chickens were allocated as G1; nucleotides and phytobiotics from day one till the end of the experiment with a dose of 200 g and 250 g/ton feed, respectively and non-challenged with Clostridium perfringens (C. perfringens), G2; nucleotides and phytobiotics treated as G1 and challenged with C. perfringens, while respectively G3 and G4 were control non-treated, challenged and non-challenged groups, The results revealed that C. perfringens challenge in treated chickens had little effects on liver functions, growth performance, immunity parameters, and gut integrity genes (Occuldin, JAM, and MUC) which indicated the beneficial effects of continuous feed supplementation with nucleotides and phytobiotics in broilers. | ||||
| Keywords | ||||
| Broiler Chickens; Gut Integrity; Liver Health; C. perfringens | ||||
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