Association between Entamoeba histolytica infection and chronic urticaria in children: A case-control study in Kirkuk | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 26 August 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2025.396763.2937 | ||||
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| Authors | ||||
Ibrahim Shaker Ibrahim  ; Ne'ma Ali Ibrahim
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| Department of Life Sciences, College of Science, University of Kirkuk, Kirkuk, Iraq | ||||
| Abstract | ||||
| Background: Persistent for more than six weeks, Chronic Urticaria (CU) is a dermatologic disorder with possible etiologies ranging from autoimmune to allergic to parasitic ones. An invading intestinal protozoan, E. histolytica has been hypothesised to set off immune reactions producing allergic reactions. This study aimed to assess the relationship between CU and infection with the parasite E. histolytica in children. Methods: 182 children total—140 with CU and 42 healthy controls—were used in a case-control analysis. Blood samples were obtained to measure IgE levels and complete blood count (CBC), and stool samples were examined microscopically to find E. histolytica. clinical symptoms were recorded and examined. Results: Comparatively to 0% of controls (p<0.00), E. histolytica was found in 85.71% of CU patients with a statistically significant difference (p<0.001). CU patients with amoebas had a significantly higher mean IgE level of 420.5 ± 115.4 ng/ml, than those of controls (186.3 ± 111.6 ng/ml). E. histolytica-positive cases more often showed elevated eosinophil counts and typical symptoms (e.g., abdominal pain, stomach pain, and itching). Conclusion: In children, the results association a noteworthy correlation between E. histolytica infection and CU. In endemic areas, urticaria patients should get screen for parasitic infections. | ||||
| Keywords | ||||
| E. histolytica; urticaria; children; IgE | ||||
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