Endothelial Activity and Stress Index (EASIX) Score as a Predictor for Early Severe COVID-Related Mortality
Elrefy, M., shoeib, S., AboZenah, A., Kassab, I., efat, A. (2025). Endothelial Activity and Stress Index (EASIX) Score as a Predictor for Early Severe COVID-Related Mortality. EKB Journal Management System, 100(1), 3842-3847. doi: 10.21608/ejhm.2025.415726.1824
Mahmoud Ahmed Elrefy; sabry shoeib; ahmed AboZenah; Ibrahim Kassab; alaa efat. "Endothelial Activity and Stress Index (EASIX) Score as a Predictor for Early Severe COVID-Related Mortality". EKB Journal Management System, 100, 1, 2025, 3842-3847. doi: 10.21608/ejhm.2025.415726.1824
Elrefy, M., shoeib, S., AboZenah, A., Kassab, I., efat, A. (2025). 'Endothelial Activity and Stress Index (EASIX) Score as a Predictor for Early Severe COVID-Related Mortality', EKB Journal Management System, 100(1), pp. 3842-3847. doi: 10.21608/ejhm.2025.415726.1824
Elrefy, M., shoeib, S., AboZenah, A., Kassab, I., efat, A. Endothelial Activity and Stress Index (EASIX) Score as a Predictor for Early Severe COVID-Related Mortality. EKB Journal Management System, 2025; 100(1): 3842-3847. doi: 10.21608/ejhm.2025.415726.1824

Endothelial Activity and Stress Index (EASIX) Score as a Predictor for Early Severe COVID-Related Mortality

The Egyptian Journal of Hospital Medicine
Volume 100, Issue 1, July 2025, Page 3842-3847  XML PDF (1.06 MB)
Document Type: Original Article
DOI: 10.21608/ejhm.2025.415726.1824
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Authors
Mahmoud Ahmed Elrefy1; sabry shoeib2; ahmed AboZenah3; Ibrahim Kassab email 4; alaa efat5
1Lecturer of Internal Medicine & Hematology / faculty of Medicine / Menoufia University
2Hematology Unit, Department Of Internal Medicine, faculty of Medicine, Menoufia University, Shebin Al Kom, Egypt
3physician at cairo university hospitals, Egypt
4Department Of Internal Medicine , Sirs Allyan General Hospital , Menoufia , Egypt
5Hematology Unit, Department Of Internal Medicine, faculty of Medicine, Menoufia University, Shebin Al Kom, Egypt
Abstract
Background: Severe COVID-19 often triggers an uncontrolled surge of pro-inflammatory cytokines, leading to endothelial injury that plays a critical role in early mortality.
Objective: This study aimed to estimate endothelial activity and stress index (EASIX) score and find out if there is association between EASIX score and early mortality in adults with severe COVID-19.
Subjects and methods: This retrospective observational analysis study included 200 adult patients diagnosed with severe COVID-19 and admitted to Menoufia University Hospitals between June and November 2021. Patients were divided into two groups: survivors and non-survivors.
Results: EASIX scores were significantly higher in non-survivors indicating a strong association with early COVID-19–related deaths. Significant differences were also noted between the two groups in hemoglobin levels, absolute lymphocyte count, D-dimer, LDH, CRP, ferritin, creatinine, and BUN values.
Conclusion: The EASIX score demonstrated excellent predictive accuracy for early mortality (AUC = 0.981) and can serve as a practical tool for assessing risk in severe COVID-19 patients.
Keywords
COVID-19; Early mortality; EASIX score; D-dimer; LDH
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