Relationship between Interleukin 21 and Activation of Natural Killer cells in Iraqi patients with CML | ||
| Journal of Medical and Life Science | ||
| Volume 7, Issue 3, September 2025, Pages 472-481 PDF (594.57 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jmals.2025.450015 | ||
| Authors | ||
| Elaf Zuhair Hmeed* 1; Baan Abdulatif Mtashar2; Aseel Majeed Hameed1; Yusra Ghiath1; Mohanad Salam Hussein1; Roaa Mokram Hamed1 | ||
| 1National center of hematology/ Mustansiriya university, Iraq | ||
| 2Microbiology Department/ College of Medicine/ Mustansiriryah University, Iraq | ||
| Abstract | ||
| Background: CML is a persistent hematological malignancy, distinguished by aberrant white blood cell growth. It is caused by a genetic abnormality that leads to the uncontrolled production of a specific type of white blood cell called a chronic myeloid leukemia cell. Preclinical findings reveal that IL-15 and IL-21 have the potential capacity to enhance the activity of NK cells, which are important for killing cancer cells. Additionally, IL-21 may help to regulate the immune response in CML, potentially reducing the risk of complications associated with the disease. Materials and Methods: Sixty-five Iraqi patients with CML were recruited from the Hematology Center in Baghdad. The participants who were on tyrosine kinase inhibitors (TKIs) and those who had just received a diagnosis were split into two groups. There was also a control group of twenty-five healthy people. The study. The IL-21 estimation by Sandwich ELISA and NK subsets detection by Flowcytometry. Results: The study observed significant changes in natural killer cell subsets between CML patients and healthy controls with differences based on treatment status. IL-21 level showed no significant variation, suggesting it may not play a key role in CML. While some NK cells subsets correlated with IL-21, the overall link with CD56 +CD 16 + NK cells was not statistically significant. | ||
| Keywords | ||
| NK cells; CML; interleukin 21; TKIs | ||
|
Statistics Article View: 109 PDF Download: 47 |
||
