Melatonin alleviates cisplatin induced liver toxicity in rats by up-regulation of Nrf2/HO-1 signaling pathway | ||
| Medicine Updates | ||
| Articles in Press, Accepted Manuscript, Available Online from 30 August 2025 PDF (1.09 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/muj.2025.410105.1250 | ||
| Authors | ||
| Soha M.Y. Mohamed1; Suzan A Khodir* 2; Noha Abd El-aziz3; Nader G Zaki3; Heba G Abdel-Fattah4; Marian F. L. Abdelmalak5; Shireen Ragab Slima6; Ekbal Elkhouli7; Mai Adawi8; Hidi A. A.Abdellatif9; Asmaa I Bayomi10; Safaa Mohamed abdel wahab11 | ||
| 1Medical Physiology Department, Faculty of Medicine Ain Shams University, Cairo, Egypt. Medical Physiology Department, Faculty of Dentistry, Misr International University, Cairo, Egypt | ||
| 2Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt. | ||
| 3Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||
| 4Tropical Medicine Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt. | ||
| 5Clinical Pharmacology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||
| 6Forensic medicine and Clinical Toxicology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt. | ||
| 7Pathology Department, Faculty of medicine Mansoura University, Egypt | ||
| 8Medical Physiology Department Department, Faculty of Medicine, Suez Canal University (SCU), Ismailia, Egypt | ||
| 9Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Suez Canal University (SCU), Ismailia 41522, Egypt; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, King Salman International University, | ||
| 10Zoology department, Faculty of Science, Menoufia University. | ||
| 11Medical Physiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt | ||
| Abstract | ||
| Background: One of the most well-known chemotherapy drugs is cisplatin (Cis). Hepatotoxicity is among the most significant adverse effects of cisplatin. The pineal gland hormone melatonin (Mel) is primarily reliant on the light/dark cycle for its cyclic release. This neurohormone can preserve tissue redox equilibrium and functions as an antioxidant. Aim: The purpose of the study was to assess hepatoprotective impact of Mel in rats exposed to Cis, as well as any possible underlying processes. Methods: Three groups of thirty adult male albino rats were created: control, Cis, and Cis+Mel. Hepatic MDA, hepatic SOD, hepatic TNF-α, hepatic IL-6, hepatic IL-10, liver-expressed Nrf2 and HO-1 genes and serum liver enzymes were measured. Additional assessments of the liver's caspase-3 and NF-kB immunoreaction were conducted. Results: Hepatic SOD, IL-10, and Nrf2 and HO-1 gene expression all significantly decline in response to cis-induced damage. Nevertheless, as compared to control, there was a notable rise in serum liver enzymes along with hepatic MDA, TNF-α, and IL-6, along with an upregulation of caspase-3 and NF-kB immunoreaction in the liver. Mel significantly improved the liver abnormalities brought on by Cis. Conclusion: Mel employed anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms in addition to up-regulating the Nrf2/HO-1 signaling cascade to reduce the hepatotoxicity brought on by Cis. | ||
| Keywords | ||
| Caspase-3. Cisplatin; Hepatotoxicity. HO-1; Melatonin. NF-kB; Nrf2 | ||
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