Association between the HLA-DRB1 with the disease activity parameters among Egyptian RA patients | ||
| ARCADEs of MEDICINE | ||
| Articles in Press, Accepted Manuscript, Available Online from 30 August 2025 | ||
| Document Type: Original Research | ||
| DOI: 10.21608/arcmed.2025.405779.1148 | ||
| Authors | ||
| ali mohamed* 1; Dahlia Abdel Mohsen Hussein2; Fatma Mohamed Badr3; Mostafa Mahmoud ElNakib4 | ||
| 1Rheumatology/AFCM | ||
| 2head of the rheumatology department/AFCM | ||
| 3AFCM | ||
| 4Military academy | ||
| Abstract | ||
| Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (ACCP), key markers of seropositivity in rheumatoid arthritis (RA), have been linked to the HLA-DRB1 allele. This study aimed to determine the prevalence of HLA-DRB1 in RA patients in tertiary hospitals and assess its association with disease severity. A total of 47 patients diagnosed according to the 2010 EULAR/ACR criteria were enrolled in this cross-sectional study. Participants underwent comprehensive clinical assessments, laboratory investigations—including RF, ACCP, CRP, ESR, liver enzymes, and HLA-DRB1 genotyping via PCR—and were evaluated using the DAS28-CRP score. Results showed that patients positive for HLA-DRB1 had significantly higher DAS28-CRP scores, elevated CRP, RF, and ACCP levels, and increased counts of swollen and tender joints compared to HLA-DRB1-negative individuals. Despite these findings, there was no statistically significant difference in disease activity classification between the two groups. Univariate logistic regression revealed a strong association between disease severity and elevated inflammatory markers. Multivariate analysis identified CRP >6 mg/L as the most significant independent predictor of moderate to severe disease (OR = 144.000, 95% CI: 11.589–178.248, P = 0.001). In conclusion, the presence of HLA-DRB1 is associated with more severe RA, reflected by higher inflammatory markers and joint involvement. However, no association was observed between HLA-DRB1 and extra-articular manifestations or comorbid conditions. | ||
| Keywords | ||
| Association; HLA-DRB1; Rheumatoid Arthritis; Human Leukocyte Antigen | ||
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