Association between the HLA-DRB1 with the disease activity parameters among Egyptian RA patients
mohamed, A., Hussein, D., Badr, F., ElNakib, M. (2025). Association between the HLA-DRB1 with the disease activity parameters among Egyptian RA patients. EKB Journal Management System, (), -. doi: 10.21608/arcmed.2025.405779.1148
ali mohamed; Dahlia Abdel Mohsen Hussein; Fatma Mohamed Badr; Mostafa Mahmoud ElNakib. "Association between the HLA-DRB1 with the disease activity parameters among Egyptian RA patients". EKB Journal Management System, , , 2025, -. doi: 10.21608/arcmed.2025.405779.1148
mohamed, A., Hussein, D., Badr, F., ElNakib, M. (2025). 'Association between the HLA-DRB1 with the disease activity parameters among Egyptian RA patients', EKB Journal Management System, (), pp. -. doi: 10.21608/arcmed.2025.405779.1148
mohamed, A., Hussein, D., Badr, F., ElNakib, M. Association between the HLA-DRB1 with the disease activity parameters among Egyptian RA patients. EKB Journal Management System, 2025; (): -. doi: 10.21608/arcmed.2025.405779.1148

Association between the HLA-DRB1 with the disease activity parameters among Egyptian RA patients

ARCADEs of MEDICINE
Articles in Press, Accepted Manuscript, Available Online from 30 August 2025  XML
Document Type: Original Research
DOI: 10.21608/arcmed.2025.405779.1148
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Authors
ali mohamed email 1; Dahlia Abdel Mohsen Hussein2; Fatma Mohamed Badr3; Mostafa Mahmoud ElNakib4
1Rheumatology/AFCM
2head of the rheumatology department/AFCM
3AFCM
4Military academy
Abstract
Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (ACCP), key markers of seropositivity in rheumatoid arthritis (RA), have been linked to the HLA-DRB1 allele. This study aimed to determine the prevalence of HLA-DRB1 in RA patients in tertiary hospitals and assess its association with disease severity. A total of 47 patients diagnosed according to the 2010 EULAR/ACR criteria were enrolled in this cross-sectional study. Participants underwent comprehensive clinical assessments, laboratory investigations—including RF, ACCP, CRP, ESR, liver enzymes, and HLA-DRB1 genotyping via PCR—and were evaluated using the DAS28-CRP score.



Results showed that patients positive for HLA-DRB1 had significantly higher DAS28-CRP scores, elevated CRP, RF, and ACCP levels, and increased counts of swollen and tender joints compared to HLA-DRB1-negative individuals. Despite these findings, there was no statistically significant difference in disease activity classification between the two groups. Univariate logistic regression revealed a strong association between disease severity and elevated inflammatory markers. Multivariate analysis identified CRP >6 mg/L as the most significant independent predictor of moderate to severe disease (OR = 144.000, 95% CI: 11.589–178.248, P = 0.001).



In conclusion, the presence of HLA-DRB1 is associated with more severe RA, reflected by higher inflammatory markers and joint involvement. However, no association was observed between HLA-DRB1 and extra-articular manifestations or comorbid conditions.
Keywords
Association; HLA-DRB1; Rheumatoid Arthritis; Human Leukocyte Antigen
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