Tocilizumab's Potential Therapeutic Effect in the therapy of Endometriosis
Fawzy, N., Badawy A, A., Salah El-Zayadi, A., Abou-EL-Naga, A. (2022). Tocilizumab's Potential Therapeutic Effect in the therapy of Endometriosis. EKB Journal Management System, 54(1), 1-5. doi: 10.21608/mjb.2022.450418
Nada Mohamed Fawzy; Ahmed Mahmoud Badawy A; Ahmed Abdelhamıd Salah El-Zayadi; Amoura Mohamed Abou-EL-Naga. "Tocilizumab's Potential Therapeutic Effect in the therapy of Endometriosis". EKB Journal Management System, 54, 1, 2022, 1-5. doi: 10.21608/mjb.2022.450418
Fawzy, N., Badawy A, A., Salah El-Zayadi, A., Abou-EL-Naga, A. (2022). 'Tocilizumab's Potential Therapeutic Effect in the therapy of Endometriosis', EKB Journal Management System, 54(1), pp. 1-5. doi: 10.21608/mjb.2022.450418
Fawzy, N., Badawy A, A., Salah El-Zayadi, A., Abou-EL-Naga, A. Tocilizumab's Potential Therapeutic Effect in the therapy of Endometriosis. EKB Journal Management System, 2022; 54(1): 1-5. doi: 10.21608/mjb.2022.450418

Tocilizumab's Potential Therapeutic Effect in the therapy of Endometriosis

Mansoura Journal of Biology
Volume 54, Issue 1, March 2022, Pages 1-5    PDF (720.88 K)
Document Type: Original Article
DOI: 10.21608/mjb.2022.450418
Authors
Nada Mohamed Fawzy* 1; Ahmed Mahmoud Badawy A2; Ahmed Abdelhamıd Salah El-Zayadi3; Amoura Mohamed Abou-EL-Naga4
1Facultyof science, Mansoura Unversity
2Prof. of Obsterics & Gynecology, Faculty of Medicine, Mansoura Unıversıty
3A. Prof. of Obsterics & Gynecology, Faculty of Medicine, Mansoura University
4Prof. of Experimental Embryology, Facultyof science, Mansoura University
Abstract
Introduction: Endometriosis is a chronic inflammatory syndrome that typically affects premenopausal women and is characterized by the growth of endometrial tissue and stromal cellbeyond the uterus.Many pro-inflammatory cytokines, particularly tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL8 and monocyte chemotactic protein-1 (MCP-1) play important roles in endometriosis pathogenesis.
Materials/ Methods:Endometriosis was studied using 18 of female Sprague rats. Animals were randomly separated into two sets: tocilizumab-treated animals and saline-treated animals.After endometrial tissues volumes were measured, immunohistochemical examination was evaluated.
Results:The treated and control groups had similar pretreatment spherical volumes (P>.05). There was a significant change between pretreatment and posttreatment implant volumes after treatment (P<.05).). Also immunohistochemistry technique show differences in immunoreaction intensity for IL6 in control and treated Group.
Keywords
Endometriosis. Cytokines. Interleukin; 6.)
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