PREVALENCE OF HUMAN EPIDERMAL GROWTH FACTOR II IN GASTROESOPHAGEAL AND GASTRIC ADENOCARCINOMA (A Multi-center study)
Mounir, A., Ibrahim, S., Hani, R., Sakr, A. (2025). PREVALENCE OF HUMAN EPIDERMAL GROWTH FACTOR II IN GASTROESOPHAGEAL AND GASTRIC ADENOCARCINOMA (A Multi-center study). EKB Journal Management System, 6(3), 206-224. doi: 10.21608/ejmr.2025.308716.1656
Ashraf Mounir; Salsabel Ibrahim; Reham Hani; Amro Sakr. "PREVALENCE OF HUMAN EPIDERMAL GROWTH FACTOR II IN GASTROESOPHAGEAL AND GASTRIC ADENOCARCINOMA (A Multi-center study)". EKB Journal Management System, 6, 3, 2025, 206-224. doi: 10.21608/ejmr.2025.308716.1656
Mounir, A., Ibrahim, S., Hani, R., Sakr, A. (2025). 'PREVALENCE OF HUMAN EPIDERMAL GROWTH FACTOR II IN GASTROESOPHAGEAL AND GASTRIC ADENOCARCINOMA (A Multi-center study)', EKB Journal Management System, 6(3), pp. 206-224. doi: 10.21608/ejmr.2025.308716.1656
Mounir, A., Ibrahim, S., Hani, R., Sakr, A. PREVALENCE OF HUMAN EPIDERMAL GROWTH FACTOR II IN GASTROESOPHAGEAL AND GASTRIC ADENOCARCINOMA (A Multi-center study). EKB Journal Management System, 2025; 6(3): 206-224. doi: 10.21608/ejmr.2025.308716.1656

PREVALENCE OF HUMAN EPIDERMAL GROWTH FACTOR II IN GASTROESOPHAGEAL AND GASTRIC ADENOCARCINOMA (A Multi-center study)

Egyptian Journal of Medical Research
Volume 6, Issue 3, July 2025, Page 206-224  XML PDF (644.48 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2025.308716.1656
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Authors
Ashraf Mounir email orcid ; Salsabel Ibrahim; Reham Hani; Amro Sakr
Departement of Clinical Oncology Cairo University
Abstract
Metastatic Gastric cancer (GC) is a prevalent disease with a median overall survival (OS) between 32-37 weeks. Targeting human epidermal growth transmembrane factor receptor 2 (HER-2) has a predictive however controversial prognostic impact. This study was conducted to reveal the incidence of HER2 status in Egyptian and Yemeni GC patients. we aimed evaluating the association between different factors and HER2 overexpression. Moreover, the factors affecting (OS) and Progression-free survival (PFS) were assessed in HER2 positive cases. Methods: This is a Multi-center retrospective study. Gastric or gastro-esophageal junction carcinoma cases were collected. Epidemiological, clinicopathological and treatment data were analyzed. The HER2 status was assessed. Survival analysis was calculated and the determinants affecting it were analyzed. Results: out of 62 patients diagnosed with GC,10 patients had HER-2 +ve disease.50 % had metastatic disease. brain metastasis (3.3%) was presented in HER2-positive cases only, while bone (10%) and peritoneal metastasis (46.7%) were presented in HER2-negative cases only. The median survival was 25 months.HER-2 -ve and HER-2 +ve subgroups were 25 and 28 months respectively (P=0.68).the median (PFS) for entire group was 12 months and for HER-2 -ve vs HER-2 +ve cases ,it was 9 months in both groups(P=0.73). conclusion: the (HER2) rate in our cohort was 16.1% . The current study has highlighted the possible association between HER2-positivity and brain metastasis in gastric cancer patients and could confirm the higher incidence of liver metastasis and absence of peritoneal metastasis in those HER2 positive patients.
Keywords
gastric cancer; GE junction; HER-2
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