Long non-coding RNA polymorphisms and expression profiles in colorectal cancer: A step toward precision medicine in Egyptian patients | ||
| Translational Health Sciences | ||
| Volume 1, Issue 2, August 2025, Pages 1-16 PDF (371.53 K) | ||
| Document Type: Review Article | ||
| DOI: 10.21608/ths.2025.405577.1010 | ||
| Author | ||
| Mahmoud A. Senousy* | ||
| Biocehmistry, Faculty of Pharmacy, Cairo Universitty, Cairo, Egypt | ||
| Abstract | ||
| Colorectal cancer (CRC) ranks among the most prevalent malignancies worldwide and remains a major contributor to cancer-related death. Genetic predisposition, particularly that involving long non-coding RNAs (lncRNAs), has come to be recognized as a significant contributor to individual susceptibility and tumor progression, despite the substantial roles played by environmental and dietary factors in the genesis of CRC. Recent findings demonstrate that lncRNAs influence microRNA networks, drive processes such as the epithelial-mesenchymal transition, and modify key signaling pathways through their polymorphisms and altered expression. Although prior work has explored lncRNA polymorphisms in general populations, data specific to Egyptian CRC patients remain limited and under-analyzed. In this mini-review, we summarize evidence from several studies conducted on Egyptian CRC patients, focusing on the association of lncRNA polymorphisms (CCAT2 rs6983267, HULC rs7763881, MALAT1 rs3200401, PVT1 rs13255292, MEG3 rs7158663 and rs941576, and HOTTIP rs1859168) and the expression profiles of their corresponding lncRNAs with CRC risk, progression, and obesity-related tumorigenesis. We further discuss their transformative potential as therapeutic targets and biomarkers and their added value in the precision medicine of CRC. | ||
| Keywords | ||
| CRC; lncRNA; miRNA; Obesity-related CRC; SNP | ||
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