Use of fennel seeds extract as a protector against high fructose diet-induced cardiac injury in male rats | ||||
| Mansoura Journal of Biology | ||||
| Volume 54, Issue 1, March 2022, Page 66-79 PDF (985.84 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjb.2022.450448 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Hadeer M. El-Nigomy* ; Mamdouh R. El-Sawi; Azza M. El-Wakf | ||||
| Department of Zoology, Faculty of Science, Mansoura University, Egypt | ||||
| Abstract | ||||
| The relation between high fructose intake and increased incidence of cardiac injury was assessed, with particular focusing on the possible protective role of oral intake of fennel seeds extract (200 mg/kg bw). Rats fed on high fructose (60%) diet for 12 weeks exhibited raised abdominal fat percent, serum glucose, insulin, leptin, HOMA-IR, and lipid profile with decreased QUICKI, reflecting a state of insulin resistance. This goes with increased myocardial lipid deposition, cardiac hypertrophy, hyperuricemia, reduced cardiac NO and hypertension. Significant reduction in cardiac antioxidants (SOD, CAT and GSH) and TAC, with elevation in oxidative stress indices (NADPH oxidase, O2.-, MDA and H2O2) and serum cardiac biomarkers (CK-MB, LDH, AST, and cTn-I) were also observed. Further elevation in cardiac NF-κβ, proinflammatory cytokines (TNF-α, IL-1β and IL-6), and adhesion molecules (ICAM-1, VCAM-1) were recorded. However, administration of fennel seeds extract has shown to reduce fructose-induced metabolic alterations, oxidative injury, inflammation and normalize blood pressure. Thus, supporting fennel seeds extract as a promising supplement against fructose- associated cardiac disease. | ||||
| Keywords | ||||
| Fructose; abdominal obesity; hypertension; cardiac disease; fennel seeds extract | ||||
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