Evaluation of Several Denture Cleansers' Efficacy Against Denture-derived Candida albicans and Comparison with Some Antifungals' Efficacy | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 April 2026 | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.387001.1664 | ||
| Authors | ||
| Ban A. Sabbar* 1; Alia M. Abdulateef2; Maysaloun AL-sadoon1 | ||
| 1Department of Microbiology, College of Medicine, Basrah University, Basrah, Iraq | ||
| 2Southren Technical University, Basrah, Iraq | ||
| Abstract | ||
| Background: One component of the oral cavity's microbiota is Candida spp. C. albicans can colonize the surface of an acrylic denture. Denture cleansers are a chemical approach that can inhibit the candidal growth.Objective : To examine the impact of some denture cleansers on denture-isolated C. albicans and compare them to certain antifungals. Methodology: Two sterile swab samples were obtained from each participant from 52 denture wearers. Samples were cultured on culture media to detect Candida growth. Sterile paper disks loaded with household chlorine, chlorhexidine digluconate, Corega tablets, salt solution, fluconazole and nystatin were tested for their antifungal effect against Candida by disk-diffusion assay.Results: 48% of denture wearers have Candida spp. The most frequent species found in denture wearers is C. albicans. According to the inhibition zone diameters, the disks loaded with household chlorine showed the strongest effect on the C. albicans and other species of Candida compared with disks loaded with other denture cleansers and antifungals. Conclusion: The growth of oral candidiasis is facilitated by wearing dentures, and one of the most often isolated species is Candida albicans. The denture-cleaning household chlorine had the highest antifungal effect on C. albicans and other Candida species, even when compared with antifungals such as fluconazole and nystatin. | ||
| Keywords | ||
| Candida albicans; Denture; Fluconazole; Household chlorine; Nystatin; Chlorhexidine digluconate | ||
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