The suppressive role of Ginkgo biloba against diclofenac induced hepatic injury. | ||||
| Mansoura Journal of Biology | ||||
| Volume 55, Issue 2, June 2022, Page 37-45 PDF (826.24 K) | ||||
| DOI: 10.21608/mjb.2022.450594 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Sally M. E. Ramadan* ; Hanaa M. Serag; Gamal M. F. Edrees | ||||
| Zoology Department-Faculty of Science-Mansoura university | ||||
| Abstract | ||||
| Many physiological problems can injure people who are treated with diclofenac (DF), Ginkgo biloba (G.b) has to exhibit a hepatic prevention effect against this injury. To estimate the dangerous role of DF and the protective role of G.b, rats treated with DF (10 mg/kg), and/or G.b at dose (100, 200, 400 mg/kg/b.wt) by intragastric administration for one and two weeks. Biochemical analysis and immunohistochemical studies were estimated. The results revealed that, DF led to an increase in the concentration of AST, ALT, and γ-GT accompanied by a decline of GSH, SOD, CAT, GPx, prostaglandin, TNF-α, IL-1 β, and IL-6. In addition to alterations in immune regulatory symptoms. Notably, supplementary G.b significantly protects the liver from these abnormalities. In conclusion, it seems that the mechanism of action of DF to induce hepatic injury may be through stimulating ROS generation and declining the antioxidant systems, triggering ionic disturbances. G.b administration can scavenge ROS and free radicals, restore the antioxidant status and exhibit a significant chemoprotective effect against DF-produced hepatotoxicity. | ||||
| Keywords | ||||
| Diclofenac; Ginkgo biloba; Transaminases; Oxidative stress and anti-oxidant; anti-inflammatory markers | ||||
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