Genetic variations of CYP2D6, CYP3A4 and CYP3A5 in systemic lupus erythematous pediatric patients | ||
| Mansoura Journal of Biology | ||
| Volume 56, Issue 3, September 2022, Pages 1-5 PDF (550.58 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjb.2022.450597 | ||
| Authors | ||
| Thuraya M. Mutawi* 1; Mohamed M. Zedan2; Mahmoud M. Zakri3; Mamdouh R. El-Sawi4 | ||
| 1Department of Laboratories, Children Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||
| 2Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||
| 3The Urology and Nephrology Center, Faculty of Science, Mansoura University, Mansoura, Egypt | ||
| 4Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| This study aimed to investigate genetic variations of CYP2D6, CYP3A4 and CYP3A5 in systemic lupus erythematous (SLE) pediatric patients. Methods: CYP2D6*2, *4, *5, *10, *41 and CYP3A4*22 and CYP3A5*3 were determined with commercially available TaqMan assays in 75 SLE patients and 145 healthy study participants. Results: The CYP2D6*2 allele was the most common variant alleles among SLE patients and the healthy participants. No homozygous mutation was detected for CYP3A4*22 in both studied groups. No significant difference in the distribution of allele frequencies was observed between the two groups. Conclusion: The results of this study confirm that there was no difference in the frequency of genetic variations in CYP2D6, CYP3A4 and CYP3A5 between controls and pediatric patients with SLE. Nonetheless, more extensive investigations with a greater number of patients are required to validate and strengthen our findings. | ||
| Keywords | ||
| Systemic lupus; CYP2D6; CYP3A4; CYP3A5; Polymorphism | ||
|
Statistics Article View: 33 PDF Download: 9 |
||
