Some Hematological Markers as Predictors of Short and Long-term Outcomes in Acute Myocardial Infarction Patients Undergoing Primary Percutaneous Intervention. | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 September 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2025.393526.1984 | ||
| Authors | ||
| Adel Hamdy Mahmoud1; Mohamed Abd el Razek Abd el Hakeem2; Amgad Nassef Makram* 3; Hany Taha Taha4 | ||
| 1Prof. of Cardiology, Faculty of Medicine, Minia University | ||
| 2Clinical pathology department, Faculty of medicine, Minia Univerisity | ||
| 3Cardiology, Faculty of Medicine, Minia University, Egypt | ||
| 4Cardiology department, Faculty of medicine, Minia university | ||
| Abstract | ||
| Background: Acute myocardial infarction (AMI) is an inflammatory disorder causing heart and blood flow changes due to inflammation and hypoxia. Blood count analysis is crucial for understanding the pathophysiology and risk assessment of AMI, as studies show essential myeloid activity. Objective: The study aimed to explore the predictive power of specific hematological and inflammatory markers in STEMI patients undergoing primary PCI, including neutrophils to platelet ratio, hemoglobin level, immature granulocyte, and systemic inflammatory index. Methods and patients: The study involved 250 patients receiving PPCI for Acute STEMI, undergoing diagnostic tests like ECG, echocardiography, CBC, Hg level, NPS, SII, and IG. Data was recorded in-hospital, angiographic, and PPCI. The endpoint was a follow-up period to 5-point MACE at 1 month, 6 months, and 1 year. Results : The study analyzed major adverse cardiac events (MACE) in patients with low hemoglobin levels, non-proliferative risk (NPR) and severity index (SII) using ROC curve analysis. The incidence of MACE was higher at 1 month, 6 months, and 1 year when Hg was low. Higher NPR was associated with worse outcomes at 1 month, 6 months, and 1 year. High SII increased the risk of MACE at 1 month, but no association was found at 6 months or 1 year. Positive IG group had increased rates of MACE at 1 month. Conclusion: Following PCI, low hemoglobin levels and high neutrophil-to-platelet ratios are significant risk factors for serious cardiovascular events. SII and IG can only predict MACE in the near run, without long-term implications. | ||
| Keywords | ||
| Hematological markers; STEMI; PPCI | ||
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