Clinical and Radiographic Evaluation of Leucocyte Platelets – Rich Fibrin in Bone Healing around Immediate Dental Implants | ||||
| Dental Science Updates | ||||
| Volume 6, Issue 2, September 2025, Page 341-352 PDF (2.25 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/dsu.2025.359308.1287 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ahmed Salah Mesalhy  1; Alaa Eldin Saad Abdel-Hameed2; Ahmad Elrawdy3; Mohamed Said Hamed4
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| 1B.D.S. Faculty of Dentistry, Suez Canal University, 2013, Dentist at the Ministry of Health | ||||
| 2Professor of Clinical Pathology, Faculty of Medicine, Suez Canal University | ||||
| 33Professor of Oral and Maxillofacial Radiology, Faculty of Dentistry, Suez Canal University | ||||
| 4Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Suez Canal University | ||||
| Abstract | ||||
| Background: Platelet-rich fibrin (PRF), is a second-generation platelet concentrate; leucocyte- and platelet-rich fibrin (L-PRF) is a modified PRF biomaterial that has been proven to enhance bone healing, therefore, may be used to promote osseointegration around immediate dental implants. Aim: To assess the utilization of L-PRF in bone healing around immediate dental implants. Patients and methods: Eighteen dental implants were placed in patients with badly decayed bilateral mandibular anterior or premolar teeth indicated for extraction and implant placement utilizing the split-mouth technique. Patients’ side was randomly allocated into two groups, (n = 9 implants/ group) where: Group I (control): The control side received immediately placed implants without L-PRF after extraction; Group II (study): The study side received immediately placed implants with L-PRF membranes placed around the osteotomy site immediately after extraction and implant insertion. Clinical assessment of implant stability was performed using the Ostell device where ISQ readings were recorded immediately after implant placement then after 6 months. Pre-operative radiographic assessment was performed via CBCT, then, post-operative follow up was carried out using periapical digital radiographs, immediate post-operative, then after 3 and 6 months; bone density was measured using IDRISI Kilimanjaro software around the implant in the osteointegration zone, which is the implant–bone interface. Results: The mean of clinical test (Ostell ISQ readings) was 62.2 (±3.8) and 67.8 (±3.4) at immediate post-operative and 68.3 (±3.6) and 81.4 (±6.17) at 6 months for both control and L-PRF groups; respectively. Upon comparing group I to group II, there was no significant difference was seen immediate post-operative between both groups, however at 6-months, a highly significant difference was observed between both examined groups where the L-PRF group exhibited significantly higher Ostell readings (p= <0.001). The mean of radiographic relative bone density was 132.6 (±15.38) and 150.5 (±13.28) immediate post-operatively, then, density values recorded 121.3 (±14.64) and 141.8 (±17) after 3 months, and 151.7 (±16.68) and 186.5 (±19.03) after 6 months for the control group and the L-PRF group respectively. Results showed statistically significant changes in the control and L-PRF groups throughout follow-ups whereas comparison between both groups showed significantly higher density values in the L-PRF group especially after 6 months. Conclusion: Use of Leucocyte-platelet-rich fibrin may show improvement in implant stability and bone healing as well as increased bone density around immediate dental implants. | ||||
| Keywords | ||||
| L-PRF; Bone Healing; Dental Implant | ||||
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