THE PUTATIVE REGENERATIVE CAPABILITY OF CELASTROL AND ITS NANOEMULSION ON OSTEOPOROTIC RATS EXPERIMENTALLY INDUCED BY OVARIECTOMY | ||||
| Dental Science Updates | ||||
| Volume 6, Issue 2, September 2025, Page 369-378 PDF (1.85 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/dsu.2025.362654.1289 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
laila F elshahed  1; doaa A. labah2; Rasha Mohamed Taha 3; Tamer H. Hassan4; Elham Fathi 3
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| 1oral biology department, faculty of dentistry, zagazig university | ||||
| 2professor of oral biology Zagazig university | ||||
| 3Faculty of Dentistry, Suez Canal University | ||||
| 4Faculty of Pharmacy, Suez Canal University | ||||
| Abstract | ||||
| Introduction: Postmenopausal osteoporosis (PMOP) is the most common bone disease in the developed world with serious public health concerns. Celastrol (CEL) has been voted as one of the top five promising natural medicine molecules which may help in PMOP management. Celastrol nanoemulsion (CTL-NE) was proved to improve the oral bioavailability, therapeutic effects of CTL. Aim of the study: To detect and compare the effect of CTL and CTL-NE on mandibular bone architecture and bone turnover markers (BTMs) in ovariectomized (OVX) rats as a model of PMOP. Materials and Methods: Two groups of sixty female rats; the OVX group and the sham group, were assigned at random. The rats in each group were further separated into three equal subgroups sixty days after OVX and sham operations. The rats in subgroup 1 were not given any treatment, those in subgroup 2 were given CTL, and those in subgroup 3 were given CTL-NE for four weeks. At the end of the experiment, blood samples were collected for biochemical analysis of bone turnover markers (BTMs), then the rats were euthanized, and their lower jaws were prepared for light microscope (LM). Results: Histological examination of OVX rats mandibular bone revealed compromised bone architecture and significant increase in BTMs compared with the normal sham ones. Interestingly OVX group showed notable improvement in bone microstructure and marked decrease in BTMs upon celastrol administration, however, the superior improvement was achieved in CTL-NE treated rats and these results were confirmed histologically and biochemically. Conclusion: Systemic administration of CTL and CTL-NE may be effective therapy for treatment of poor bone quality in OVX induced osteoporosis, with privilege to CTL-NE therapy. | ||||
| Keywords | ||||
| Celastrol; Nanoemulsion; bone turnover markers; Osteoporosis; Ovariectomy | ||||
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