Impact of Oxford vaccine during pregnancy on tooth germ development and hard tissue thickness in the albino rats offspring | ||
| Dental Science Updates | ||
| Volume 6, Issue 2, September 2025, Pages 441-450 PDF (1.92 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/dsu.2025.386317.1304 | ||
| Authors | ||
| Lama Essam Dawoud* 1; Enas M. Hegazy2; Elham Fathy Mahmoud3 | ||
| 1Department of Oral Biology, Faculty of dentistry, Suez Canal University | ||
| 2Department of Oral Biology, Faculty of Dentistry, Suez Canal University | ||
| 3Oral Biology, Faculty of Dentistry, Suez Canal University | ||
| Abstract | ||
| Introduction: Teeth development and eruption are complicated events embracing plenty of structures and signaling pathways. Severe acute respiratory syndrome coronavirus-2 is the causative agent of coronavirus infectious disease-2019 (COVID-19). Pregnant females infected with COVID-19 have disturbances in the inflammatory reaction that would lead to a severe disease; therefore, their vaccination is obligatory. Materials and Methods: Pregnant female rats were equally distributed into two groups: Control group received saline and treated group received COVID-19 vaccine. At the proposed time, pups were euthanized, and the mandible of each pup was dissected for histological examination. Histomorphometric examination was performed for the thickness of enamel and dentin of the lower first molar on the 9th and 14th postnatal days. Results: Developmental stages of the lower first molar tooth germ in both groups were nearly comparable with no histological differences. Enamel thickness increased in a non-statistically significant manner in the treated group (P-value ≥ 0.05) while dentin thickness increased in a statistically significant manner in the treated group at the same time points (P-value ≤ 0.05). Conclusion: Vaccination of pregnant mothers did not influence the development of lower first molar tooth germ in the offspring. However, hard tissue thickness may be affected by vaccination. | ||
| Keywords | ||
| Development; Vaccine; Offspring; Pregnancy | ||
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