ADJUNCTIVE EFFECT OF PROPOLIS GEL TO NON-SURGICAL STAGE II PERIODONTITIS THERAPY: A CLINICAL AND IMMUNOLOGICAL STUDY | ||
| Dental Science Updates | ||
| Volume 6, Issue 2, September 2025, Pages 281-288 PDF (792.55 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/dsu.2025.323872.1282 | ||
| Authors | ||
| aya dawoud* 1; mohamed ali2; marwa mohamed azzab3; Abdel Nasser Mohammed Hashem4 | ||
| 1oral medicine and periodontology, Suez Canal university, Ismailia, Egypt | ||
| 2oral medicine and periodontology, Suez Canal University | ||
| 3professor of microbiology and immunology, faculty of pharmacy, Suez Canal university | ||
| 4oral medicine and periodontology department, faculty of dentistry, suez canal university | ||
| Abstract | ||
| ABSTRACT Introduction: Periodontitis affects more than 1/2 of adults over the age of 30. Scaling and root planning is a non-surgical, gold standard that determines important objectives to control bacterial infections and reduce inflammation related to periodontal plaque. In recent years, natural products have become increasingly popular; Propolis is a natural material produced by bees and ieffective in treating periodontal disease. Aim: This study was designed to evaluate the effect of propolis gel as an adjunctive non-surgical treatment on improving clinical parameters (PI, GI) and reducing proinflammatory mediator (IL1, IL6) levels in stage II periodontitis. Methodology: Sixty patients with stage II periodontitis will be selected from the out- patient clinic of Oral Medicine and Periodontology Department, Faculty of Dentistry, Suez Canal University. Moreover, it will be divided randomly into two equal groups. Control group: will receive scaling and root planning only. Test Group: will receive scaling and root planning and propolis gel adjunctive to non-surgical therapy. At baseline, 1 month and 3 months and for each group clinical parameters (PI, GI) assessed and proinflammatory mediators (IL1, IL6). Results in the intergroup comparison of IL1 and IL6 levels at different time intervals, the propolis group showed a statistically significant decrease in IL1 and IL6 levels compared to the SRP. The mean IL-1 was lower in the study group than in the control group after 1 month and 3 months. (p-value). In the intergroup comparison of clinical parameters (Gingival index, plaque index) at different time intervals there is no statistically significant difference. Conclusion: Subgingival delivery of propolis gel showed enhanced results as an adjunct to SRP in patients with stage II periodontitis as assessed by clinical and biochemical parameters. | ||
| Keywords | ||
| IL1; IL6; non-surgical; Periodontitis; propolis gel | ||
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