The Role of Interleukin-18 in Egyptian Patients Infected with Chronic Hepatitis C Virus and Treated with Sofosbuvir | ||||
| Al-Azhar University Journal of Medical and Virus Researches and Studies | ||||
| Volume 7, Issue 1, December 2025, Page 42-51 PDF (362.55 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aujv.2025.450866 | ||||
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| Abstract | ||||
| IL-18 belongs to the IL-1 family. According to recent studies, IL-18 may contribute to the aetiology of liver damage in both acute and chronic hepatitis, as well as the beginning and progression of liver fibrosis. The goal of this study is to determine how interleukin 18 influences how effectively individuals with hepatitis and hepatitis C in Egypt respond to Sofosbuvir therapy. The current study included 400 individuals with HCV, who were recruited at random. Every sample was acquired from Egypt's Sohag Hospital, and the trial ran from January 1, 2020 to January 30, 2022. To identify HCV RNA, all samples were tested with reverse transcriptase polymerase chain reaction (RT-PCR), and anti-HCV antibodies were detected using the ELIZA approach. All patients were treated with Sofosbuvir. According to our findings, 354 (88.5%) of the 400 people who received sofosbuvir for Hepatitis C had treatment-related side effects, whereas just 46 (11.5%) did not. We randomly selected 80 individuals, 40 of whom responded positively to pharmaceutical therapy and 40 who did not. Blood samples were taken during routine clinic visits for various tests.We looked at two patient populations: those who responded to sofosbuvir treatment (n = 40) and those who did not respond (n = 40). (patients with positive HCV RNA and anti-HCV antibodies). Our study found that those who respond to sofosbuvir treatment had lower levels of interleukin-18 after treatment, but those who do not receive sofosbuvir treatment have greater levels of interleukin 18. Hepatitis C Virus. | ||||
| Keywords | ||||
| Hepatitis C Virus; Sofosbuvir; Treatment; Side effect; Complication. interleukin-18 | ||||
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