Evaluation of Response to Treatment of Helicobacter Pylori Infection in Portal Hypertensive HCV Cirrhotic Patients | ||
| African Journal of Gastroenterology and Hepatology | ||
| Volume 8, Issue 1, 2025, Pages 113-126 PDF (600.79 K) | ||
| Document Type: Original Clinical | ||
| DOI: 10.21608/ajgh.2025.400335.1087 | ||
| Authors | ||
| mohamed gamal abdrabu* 1; Hussien mahmoud Saad2; hanaa elhoushy3; sara asar4 | ||
| 1lecturer at tropical medicine department,alexandria faculty of medicine | ||
| 2internal medicine department.GIT unit,faculty of medicine .Alexandria university | ||
| 3Department of Medical Education, Faculty of Medicine Alexandria University, Alexandria, Egypt | ||
| 4Medical Microbiology and Immunology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt | ||
| Abstract | ||
| Background: Helicobacter pylori is an etiology of various gastrointestinal disorders such as chronic gastritis, peptic ulcer, and stomach cancer. Aim: The aim was to assess the response to Helicobacter pylori treatment in patients with portal hypertensive hepatitis C virus (HCV) cirrhosis. Methods: two groups; Group A (case group): 52 H. pylori-positive HCV portal hypertensive cirrhotic cases. Group B (control group): 52 H. pylori-positive non-portal hypertensive, non-cirrhotic individuals. Both groups were given levofloxacin-based therapy (Levofloxacin 500 mg / Amoxicillin 1 g bid/ Pantoprazole 40 mg bid) for 2 weeks. The H. pylori stool antigen test was repeated 4 weeks after treatment. Results: A statistically significant difference was obtained regarding H. pylori antigen testing before and after treatment in the control group compared to the case group. Conclusion: H. pylori infection is associated with a better treatment response in non-cirrhotic, non-portal hypertensive patients compared to those with HCV-cirrhosis and portal hypertension. | ||
| Keywords | ||
| Helicobacter pylori; portal hypertension; HCV-cirrhosis; treatment; Levofloxacin; Pantoprazole | ||
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