Evaluation of Response to Treatment of Helicobacter Pylori Infection in Portal Hypertensive HCV Cirrhotic Patients | ||||
| African Journal of Gastroenterology and Hepatology | ||||
| Articles in Press, Corrected Proof, Available Online from 15 September 2025 PDF (600.79 K) | ||||
| Document Type: Original Clinical | ||||
| DOI: 10.21608/ajgh.2025.400335.1087 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
mohamed gamal abdrabu   1; Hussien mahmoud Saad 2; hanaa elhoushy3; sara asar4
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| 1lecturer at tropical medicine department,alexandria faculty of medicine | ||||
| 2internal medicine department.GIT unit,faculty of medicine .Alexandria university | ||||
| 3Department of Medical Education, Faculty of Medicine Alexandria University, Alexandria, Egypt | ||||
| 4Medical Microbiology and Immunology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt | ||||
| Abstract | ||||
| Background: Helicobacter pylori is an etiology of various gastrointestinal disorders such as chronic gastritis, peptic ulcer, and stomach cancer. Aim: The aim was to assess the response to Helicobacter pylori treatment in patients with portal hypertensive hepatitis C virus (HCV) cirrhosis. Methods: two groups; Group A (case group): 52 H. pylori-positive HCV portal hypertensive cirrhotic cases. Group B (control group): 52 H. pylori-positive non-portal hypertensive, non-cirrhotic individuals. Both groups were given levofloxacin-based therapy (Levofloxacin 500 mg / Amoxicillin 1 g bid/ Pantoprazole 40 mg bid) for 2 weeks. The H. pylori stool antigen test was repeated 4 weeks after treatment. Results: A statistically significant difference was obtained regarding H. pylori antigen testing before and after treatment in the control group compared to the case group. Conclusion: H. pylori infection is associated with a better treatment response in non-cirrhotic, non-portal hypertensive patients compared to those with HCV-cirrhosis and portal hypertension. | ||||
| Keywords | ||||
| Helicobacter pylori; portal hypertension; HCV-cirrhosis; treatment; Levofloxacin; Pantoprazole | ||||
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