Ameliorating effect of Azolla pinnata extract and its nanosized bilosomes against 5-Fluorouracil-induced hepato-renal toxicity in male rats | ||
| Menoufia Veterinary Medical Journal | ||
| Volume 1, Issue 2, July 2025, Pages 1-16 PDF (1.15 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/vmmj.2025.415686.1058 | ||
| Authors | ||
| Aya Galal AbdAlhameed* 1; Mohamed Hamdy El-Hewaity2; Amany Abd El baky El-Mleeh3; Mostafa Abdelgaber Mohamed4; Ahmed El-Shenawy5 | ||
| 1Pharmacology and veterinary preparations, Faculty of veterinary Medicine, Menoufia University, Shebin El-kom, Egypt | ||
| 2Department of Pharmacology and veterinary preparations, Faculty of veterinary Medicine, Menoufia University, Shebin El-kom, Egypt | ||
| 3Department of Pharmacology and veterinary preparation, Faculty of veterinary Medicine, Menoufia University, Shebin El-kom, Egypt | ||
| 4Department of Pathology, Faculty of Veterinary Medicine, Menoufia University, Shebin El-kom, Egypt | ||
| 5Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt | ||
| Abstract | ||
| The present study aimed to show the ameliorating effect of Azolla pinnata against hepatorenal toxicity caused by fluorouracil (5-FU). Forty-nine Wistar male rats that were weighted from 100-115gram were distributed randomly into 7 groups (n=7). Group I received 1ml DW orally daily, Group II received 1ml SDCh (Sodium deoxycholate) orally daily, Group III received 5-FU IP on the 11th experimental day in dose 150mg/kg body weight, Group IV received an AP (Azolla pinnata) orally daily in dose 10mg/kg body weight, Group V received an APN (Azolla pinnata nanosized bilosomes) orally daily 10% of 10mg/kg body weight, Group VI received an AP orally daily in dose 10mg/kg body weight and 5-FU IP on the 11th experimental day in dose 150mg/kg body weight, Group VII received an APN orally daily 10% of 10mg/kg body weight and 5-FU IP on the 11th experimental day in dose 150mg/kg body weight. The experiment lasted 21 days. On the 22nd day, blood and tissues were gathered for determination of liver and kidney functions, antioxidants and histopathological studies. Our results showed that elevated ALT, AST, urea, creatinine, uric acid, MDA and NO and reduced SOD, GSH, CAT and TAC in 5-FU group when compared to other groups. Abnormal changes in liver and kidney tissues than other groups according to histopathological studies. AP has anti-inflammatory and antioxidant effects that play role in decreasing hepatorenal toxicity caused by 5-FU. | ||
| Keywords | ||
| Azolla pinnata nanosized bilosomes; Sodium deoxycholate; Fluorouracil; Antioxidants; Histopathological studies | ||
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