Serum syndecan-1 levels and its relationship to disease activity in patients with ulcerative colitis | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Articles in Press, Accepted Manuscript, Available Online from 03 September 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2025.415220.1822 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Nourhan Assem Aly  1; Alaa Mohamed Mohamed2; Ahmed Elsaady Mohamed3; Enas Mahmoud Fouda4
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| 1internal medicine department faculty of medicine Ain Shams University | ||||
| 2internal medicine department faculty of medicine Ain Shams university | ||||
| 3Internal Medicine Department faculty of medicine Ain Shams University | ||||
| 4Internal Medicine Department Faculty of Medicine Ain Shams University | ||||
| Abstract | ||||
| Background: A chronic inflammatory bowel disease (IBD), ulcerative colitis (UC) specifically impacts the rectum and colon. It is characterized by frequent flare-ups of ulceration and inflammation in the colon lining. Both of the major types of IBD are ulcerative colitis and Crohn's disease. This study aims to evaluate the relationship between serum syndecan-1 levels and disease activity in UC cases Patients and Methods: This observational cross-sectional study involved 84 participants divided into three groups: Group A (active diseased group), consisting of 28 individuals with active UC; Group B (remission group), comprising 28 individuals with UC in remission; and Group C (normal population control group), consisting of 28 healthy individuals. Biochemical and clinical markers were compared across the groups to better understand the differences between active disease, remission, and healthy controls. Conclusions: This work underscores the significant role of serum syndecan-1 as a possible indicator for assessing the severity and activity of UC. Elevated serum syndecan-1 levels were strongly associated with clinical symptoms and objective measurements, including CRP, ESR, and fecal calprotectin, as well as colonoscopy findings in various colon regions. These results suggest that serum syndecan-1 may be a reliable non-invasive indicator for monitoring treatment response and disease progression in UC patients. | ||||
| Keywords | ||||
| Keywords: Serum syndecan-1; Disease activity; Ulcerative colitis disease | ||||
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