The Effect of Low-level Laser Therapy as an Adjunct to Non-surgical Therapy on Inducible Nitric Oxide Synthase Salivary Levels in Different Age Groups of Patients: A Randomized Clinical Trial
Mousa, A., Nassar, H., Elsaid, A. (2025). The Effect of Low-level Laser Therapy as an Adjunct to Non-surgical Therapy on Inducible Nitric Oxide Synthase Salivary Levels in Different Age Groups of Patients: A Randomized Clinical Trial. EKB Journal Management System, 12(1), 1-8. doi: 10.21608/azdj.2025.451089
Alaa Allah H. Mousa; Hamdy A. Nassar; Amal A. Elsaid. "The Effect of Low-level Laser Therapy as an Adjunct to Non-surgical Therapy on Inducible Nitric Oxide Synthase Salivary Levels in Different Age Groups of Patients: A Randomized Clinical Trial". EKB Journal Management System, 12, 1, 2025, 1-8. doi: 10.21608/azdj.2025.451089
Mousa, A., Nassar, H., Elsaid, A. (2025). 'The Effect of Low-level Laser Therapy as an Adjunct to Non-surgical Therapy on Inducible Nitric Oxide Synthase Salivary Levels in Different Age Groups of Patients: A Randomized Clinical Trial', EKB Journal Management System, 12(1), pp. 1-8. doi: 10.21608/azdj.2025.451089
Mousa, A., Nassar, H., Elsaid, A. The Effect of Low-level Laser Therapy as an Adjunct to Non-surgical Therapy on Inducible Nitric Oxide Synthase Salivary Levels in Different Age Groups of Patients: A Randomized Clinical Trial. EKB Journal Management System, 2025; 12(1): 1-8. doi: 10.21608/azdj.2025.451089

The Effect of Low-level Laser Therapy as an Adjunct to Non-surgical Therapy on Inducible Nitric Oxide Synthase Salivary Levels in Different Age Groups of Patients: A Randomized Clinical Trial

Al-Azhar Journal of Dentistry
Volume 12, Issue 1, January 2025, Pages 1-8    PDF (465.67 K)
Document Type: Original Article
DOI: 10.21608/azdj.2025.451089
Authors
Alaa Allah H. Mousa* 1; Hamdy A. Nassar* 2; Amal A. Elsaid* 2
1Teaching Assistant of Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology. Faculty of Dental Medicine for Future University in Egypt.
2Department of Oral Medicine, Periodontology, Oral Diagnosis, and Dental Radiology, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt
Abstract
Purpose: The present clinical investigation aimed to evaluate the effect of low-level laser treatment on the clinical pa- rameters and checking levels of inducible nitric oxide synthase (iNOS) in individuals with stage II periodontitis across various age groups. Patient and methods: The current investigation has been carried out on 44 locations in 44 patients. Randomly selected locations were chosen from each studied case, and divided into four groups: group A consisted of 11 sites in elderly patients who underwent scaling combined with root planning exclusively. Group B included 11 sites in young patients who also got scaling and root planning exclusively, group C 11 sites in old age who received diode laser therapy, and group D: 11 sites in young age group received low-level laser (diode laser). The clinical examination used the following clinical parameters: clinical attachment level, plaque index, and Gingival index. An Enzyme-Linked Immunosorbent Assay study was conducted on iNOS. Results: Baseline and 3-month postoperative groups were compared and showed significant differences in iNOS levels which was influenced by the treatment in the young age group (nonsurgical and laser), but showed no significant difference in the old age group on both types of treatment (nonsurgical and laser). Conclusion: This clinical investigation showed that whereas non-surgical techniques in conjunction with low-level laser treatment were unsuccessful in the elderly population, it was helpful in the young group with stage II periodontitis.
Keywords
Diode laser; Inducible nitric oxide synthase; Inflammageing; Old age; Periodontal disease
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