Expression of CD47, Aldehyde Dehydrogenase, and SOX4 Stem Cells in Different Colonic Lesions
Badran, M., Rozik, M., Hammam, O., EL Hawary, M., El Sisi, M., Soliman, M. (2025). Expression of CD47, Aldehyde Dehydrogenase, and SOX4 Stem Cells in Different Colonic Lesions. EKB Journal Management System, 2025(4), 272-277. doi: 10.21608/aimj.2025.446536
Mohammed Abd El Salam Abd El Fattah Badran; Mohamed Said Rozik; Olfat Ali Hammam; Mostafa Abdel Alaziz EL Hawary; Mohamed Hamza El Sisi; Moataz Yousry Soliman. "Expression of CD47, Aldehyde Dehydrogenase, and SOX4 Stem Cells in Different Colonic Lesions". EKB Journal Management System, 2025, 4, 2025, 272-277. doi: 10.21608/aimj.2025.446536
Badran, M., Rozik, M., Hammam, O., EL Hawary, M., El Sisi, M., Soliman, M. (2025). 'Expression of CD47, Aldehyde Dehydrogenase, and SOX4 Stem Cells in Different Colonic Lesions', EKB Journal Management System, 2025(4), pp. 272-277. doi: 10.21608/aimj.2025.446536
Badran, M., Rozik, M., Hammam, O., EL Hawary, M., El Sisi, M., Soliman, M. Expression of CD47, Aldehyde Dehydrogenase, and SOX4 Stem Cells in Different Colonic Lesions. EKB Journal Management System, 2025; 2025(4): 272-277. doi: 10.21608/aimj.2025.446536

Expression of CD47, Aldehyde Dehydrogenase, and SOX4 Stem Cells in Different Colonic Lesions

Al-Azhar International Medical Journal
Volume 2025, Issue 4, April 2025, Page 272-277  XML PDF (379.59 K)
Document Type: Original Article
DOI: 10.21608/aimj.2025.446536
View on SCiNiTO View on SCiNiTO
Authors
Mohammed Abd El Salam Abd El Fattah Badran1; Mohamed Said Rozik1; Olfat Ali Hammam2; Mostafa Abdel Alaziz EL Hawary1; Mohamed Hamza El Sisi1; Moataz Yousry Solimanorcid 1
1Hepatology, Gastroenterology, and Infectious Diseases, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt
2Pathology, Theodor Bilharz Research Institute, Cairo, Egypt
Abstract
Background: Colorectal cancer (CRC) patients have a higher likelihood of a favorable outcome when diagnosed early.
Aime: This study aimed to evaluate the expression of CD47, Aldehyde Dehydrogenase (ALDH), SOX 4 stem cells in cancerous and precancerous colonic lesions.
Patients and methods: A cross-sectional study was conducted on 100 patients at Al-Azhar University and Theodor Bilharz Research Institute. Patients were categorized into three groups: normal colonic mucosa (n=20), precancerous lesions (n=40), and CRC (n=40). Immunohistochemical staining was performed for CD47, ALDH, and SOX4.  Results: The expression levels of CD47, ALDH, and SOX4 were significantly higher in CRC patients compared to normal and precancerous groups (P ≤ 0.001). Sox4 was positive in 72.5% of CRC cases compared to 27.5% in polyps, while ALDH and CD47 were highly expressed in CRC (82.5% and 70%, respectively).
Conclusion: The study reveals significant differences in pathological characteristics between normal, precancerous, and colorectal cancer groups. Elevated Sox4, ALDH, and CD47 expression in colorectal cancer patients suggests their potential as biomarkers for cancer progression and early detection, offering potential therapeutic targets in colorectal cancer management.
Keywords
CD47; Aldehyde Dehydrogenase; SOX 4; Colonic Lesions; CRC; Ulcerative colitis
Statistics
Article View: 1