The Role of Prophylactic Use of Low Dose Aspirin and Calheparin in Patients with Unexplained Recurrent Abortion | ||||
| Al-Azhar International Medical Journal | ||||
| Volume 2025, Issue 4, April 2025, Page 300-305 PDF (454.23 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aimj.2025.446541 | ||||
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| Authors | ||||
| Taher Mohamed Mustafa Hassan; Abdelrahman Ragab Rashed; Mostafa Mamdoh Rady Ali | ||||
| Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Two or more miscarriages occurring within a 20-week window constitute recurrent pregnancy loss (RPL). A small percentage of pregnancies (1% to 5%) involve RPL. The causes of miscarriage are unknown in 40% of cases, which is categorized as an unjustified RPL (URPL), even though many factors are involved in approximately 60% of RPLs. These factors include environmental factors, stress, chromosomal abnormalities, coagulation protein defects, anatomic endocrine disorders, and the autonomic immune system. Aim and objectives: To assess the efficacy of low-dose aspirin and calheparin used as a preventative measure in women experiencing unexplained recurrent abortions. Patients and methods: The study was a prospective interventional study that included 60 patients who were selected from attendee of out-patient Obstetrics and Gynecology clinics of Al-Azhar at Al-Hussien and Sayed Gala University Hospitals from January 2024 till December 2024. Samples were collected using a random systematic method. Results: Regarding the outcome, 46 (76.67%) patients passed the first trimester, whereas abortion occurred in 14 (23.33%) patients. Conclusion: For women experiencing unexplained repeated abortions, a safe and effective treatment option is a combination of low-dose aspirin and calheparin, which can reduce the abortion rate and help them safely pass the first trimester. There is a small risk of temporary thrombocytopenia, gastrointestinal problems, bruising at the injection site, epistaxis, and bleeding gums when women with unexplained recurrent abortions take a low dose of aspirin and calheparin. | ||||
| Keywords | ||||
| Calheparin; Recurrent abortion; Low dose aspirin | ||||
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