Dynamin-Related Protein 1 (Drp1) Tissue Expression in Vitiligo Patients | ||||
| Benha Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 06 September 2025 PDF (601.36 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2025.387639.2428 | ||||
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| Authors | ||||
Asmaa Said Abd Elmoneim  1; Menha A. Ibrahim2; Shiemaa A k. Dawa3; Aml Y. Habashy4
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| 1M.B.B.Ch. Faculty of Medicine, Cairo University | ||||
| 2Assistant professor of Dermatology, Venerology and Andrology Faculty of Medicine, Benha University | ||||
| 3Assistant professor of Pathology Faculty of Medicine, Benha University Department of pathologty , Faculty of Medicine - Banha University | ||||
| 4Lecturer of Dermatology, Venerology and Andrology Faculty of Medicine - Benha University | ||||
| Abstract | ||||
| Background: Vitiligo is a chronic skin condition causing depigmented patches due to melanocyte loss, with psychological and quality-of-life impacts. Mitochondrial dysfunction, particularly involving Drp1, contributes to cellular stress and may play a role in vitiligo. Understanding Drp1's involvement could offer new insights and therapeutic targets for the disease. Aim: The current study aimed to assess the tissue expression of Drp1 in vitiligo lesional and perilesional skin. Patients and methods: This comparative cross-sectional study was conducted on 42 vitiligo patients at Benha University Hospital. Patients underwent clinical evaluations, including history taking, dermatological exams, Vitiligo Area Scoring Index (VASI) and Vitiligo Disease Activity Score (VIDA) and Wood's lamp analysis. Immunohistochemical analysis was performed on skin biopsies to assess Drp1 expression, with staining intensity and epidermal layer involvement scored systematically. Results: Most vitiligo patients were middle-aged females, with stress as the most common trigger and extremities as the most affected site. DRP-1 levels were significantly higher in lesional skin, with greater extension to all epidermal layers compared to perilesional areas. However, DRP-1 scores showed no significant correlation with clinical features such as age, disease extent, VASI, or VIDA scores Conclusion: Drp1 expression is significantly higher in lesional skin of vitiligo patients, suggesting its key role in disease pathogenesis and its potential role as a therapeutic target. | ||||
| Keywords | ||||
| Drp1; Immunohistochemistry; Lesional skin; Mitochondrial dysfunction; Vitiligo | ||||
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