Effect of Nanoparticles of Moringa oleifera Leaves Extract and\ or Low Doses of Gamma Radiation on Renal Injury Induced in Rats by Acute Pancreatitis | ||
| Egyptian Academic Journal of Biological Sciences, B. Zoology | ||
| Volume 17, Issue 2, December 2025, Pages 55-79 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsz.2025.451531 | ||
| Authors | ||
| Safaa M. Abd El-hameed1; Mona M. El-Tonsy1; Neamat H. Ahmed2; Hemmat M. Abdelhafez1 | ||
| 1Zoology and Entomology Department, Faculty of Science AL-Azhar University (Girls)-Naser city-Cairo, Egypt. | ||
| 2Cell Biology& Histology National Center for Radiation Research and Technology Egyptian Atomic Energy Authority,Cairo, Egypt. | ||
| Abstract | ||
| Background: One of the most prevalent conditions in gastroenterology is acute pancreatitis. Acute kidntey damage (AKI) is a significant indicator of morbidity and mortality and a frequent, major side effect of severe acute pancreatitis (SAP). Several drug classes may be transported by nanoparticles. Without any issues, the nutritional and biochemical properties of Moringa oleifera nanoencapsulated suggested a potential anti-hyperglycemic benefit. Low-dose gamma radiation can boost the activity of the immune system's effectors and stimulate the immune system. Aim of the work: This study is designed to evaluate the effect of nano-Moringa Oleifera leaves extract and/or low dose gamma irradiation on acute pancreatitis induced by L-arginine on the kidney tissues of rats. Materials and Methods: Fifty adult male rats were categorized in five separated groups. Group I: control group (C), group 2: positive control group (PC): L-arginine (250 mg/100g body weight) was administered intraperitoneally to the rats twice at 1-hour intervals, every other day for 14 days in order to cause acute pancreatitis, group 3: nano-Moringa oleifera treated group (NM): the positive control animals were treated with nano-Moringa oleifera (50 mg/kg/day) daily for 14 days, group 4: gamma irradiated group (IR): the positive control animals were exposed to 0.25 Gy x2 / week for 2weeks, group 5: nano-Moringa oleifera + gamma irradiated treated group (NM + IR ): the positive control animals were treated with NM (50 mg/Kg/day) twice at 1-hour intervals, day by another day for 14 days and were exposed to 0.25 Gy x2/week for 2weeks. The experimental rats were sacrificed after one day of treatments; kidney functions, plasma insulin growth factor 1 (IGF1) level and C- Reactive Protein (CRP) and plasma pancreatic enzymes (lipase and amylase) , histopathological and histochemical changes in renal tissue were evaluated. Results: rats suffered from PC revealed a significant increase in creatinine, urea, CRP, lipase and amylase while a significant decrease in IGF1, along with severe renal tissue damage. Treatment of experimental animals suffered from PC with NM and γ-irradiation either alone or combined, a remarkable decreased creatinine, urea, CRP, lipase and amylase while remarkable increase in IGF1, resulting in notable amelioration of kidney tissues damage. Conclusion: To minimize the kidney damage induced by acute pancreatitis, it is recommended to use nano-Moringa and low γ-irradiation, either separately or in combination. | ||
| Keywords | ||
| Acute pancreatitis; nano-Moringa oleifera; low dose γ-irradiation; kidney; β– amyloid protein; apoptosis. | ||
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