Cytology with cell block evaluation of non-adenocarcinomatous exfoliated malignancies in pleural and peritoneal fluids- A series of five rare cases | ||
| Journal of Medical and Life Science | ||
| Articles in Press, Accepted Manuscript, Available Online from 07 September 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jmals.2025.400246.1057 | ||
| Author | ||
| BIDHAN CHANDRA DAS* | ||
| Nalbari Medical College & Hospital, Assam, India | ||
| Abstract | ||
| Malignant effusions have been known to affect humans since ancient times and are most commonly linked with adenocarcinomas originating from organs such as the lung, ovary, colon, and breast. However, in certain cases, non-adenocarcinomatous malignant cells such as those from squamous cell carcinoma, mesothelioma, and sarcoma may also be found in the effusion fluid. This retrospective case series includes five instances of non-adenocarcinomatous malignancies identified in pleural and peritoneal fluids at a tertiary care hospital over a one-year period (January to December 2024). Cytomorphological analysis of the neoplastic effusions was conducted using MGG and PAP stains. Additionally, H&E-stained tissue sections from cell blocks were examined, and immunohistochemical tests (EMA, Calretinin, and CD20) were used as supplementary tools for diagnosis. Among the five cases studied, one case each of squamous cell carcinoma, transitional cell carcinoma, mesothelioma, lymphoma, and dysgerminoma was identified. Histopathological examination of cell blocks, supported by immunohistochemistry, is crucial in identifying the type of malignancy present in effusions. This approach is particularly important for distinguishing between metastatic epithelial cells and reactive mesothelial cells in cases where the diagnosis is complex. | ||
| Keywords | ||
| Cytology; Non-adenocarcinomatous malignancies; Pleural and peritoneal fluids | ||
|
Statistics Article View: 9 |
||
