Epicardial fat thickness in children with CAH | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 07 September 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2025.417467.2089 | ||
| Authors | ||
| Samira Zain Sayed1; Ghada Sayed Abdelaziz* 2; Amr Mostafa Setohi Abdelhafez3; Noura Mohammed ElBakry4 | ||
| 1Professor of Pediatrics, Faculty of Medicine, Minia University | ||
| 2MBBCH, Faculty of Medicine, Minia University | ||
| 3cardiology department ,faculty of medicine ,minia university | ||
| 4Pediatric Department, Faculty of Medicine, Minya University, Egypt | ||
| Abstract | ||
| Background: Congenital adrenal hyperplasia (CAH) was an autosomal recessive disorder originating from abnormalities in enzymes necessary for adrenal steroid production. 21-hydroxylase deficiency was predominant enzymatic abnormality responsible for (CAH). 21-hydroxylase deficiency may adversely impact vascular architecture & cardiac systolic & diastolic function. Aim: To evaluate cardiovascular consequences in pediatric cases with congenital adrenal hyperplasia. On long term of steroid therapy Patients and methods: This comparative cross-sectional case-control study comprised 40 children: 20 children diagnosed with classic CAH (case group). Assessments indicated increased concentrations of adrenocorticotropic hormone (ACTH), 17-hydroxyprogesterone (17-OHP), testosterone, alongside diminished morning & evening cortisol levels. (SW) variant was recognized in cases with significant hyponatremia & hyperkalemia. & twenty age- & sex-matched healthy children (control group). Inclusion Criteria: All children with CAH, aged from 1-16 years and starting the period of our study from October 2024, on treatment for at least 6 months, treated at a single tertiary hospital and written consent and Permission from the father or the mother. Exclusion criteria: children with comorbidities as renal diseases that may affect blood pressure measurement or cardiac output, children diagnosed with other congenital heart diseases that may affect blood pressure measurement or cardiac output and newly diagnosed patient (less than 6 months), patient on any treatment that may affect cardiovascular system except hydrocortisone & mineralocorticoid and poor control or poor compliance for CAH _ hormonal therapy _ ( last 17-OH progesterone serum level was above 10ng/dl ) or manifested by electrolyte imbalance or high ACTH serum level or low cortisol | ||
| Keywords | ||
| Congenital Adrenal Hyperplasia; Children; Cardiovascular Morbidities; Echocardiography | ||
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