Comparative Study of Intensity Modulated Radiotherapy, Volumetric Modulated Arc Therapy versus Three Dimensional Radiotherapy in High Grade Glioma Patients
Hanna, A., Elsayed, N., Obaya, A., Mostafa, E., Khalil, N., Mohammed, A. (2025). Comparative Study of Intensity Modulated Radiotherapy, Volumetric Modulated Arc Therapy versus Three Dimensional Radiotherapy in High Grade Glioma Patients. EKB Journal Management System, (), -. doi: 10.21608/zumj.2025.402496.4045
Amira Hany Hanna; Nehal Gamal Elsayed; Ahmed A. Obaya; Emad Mostafa; Nesma Salah Khalil; Amira Elwan Mohammed. "Comparative Study of Intensity Modulated Radiotherapy, Volumetric Modulated Arc Therapy versus Three Dimensional Radiotherapy in High Grade Glioma Patients". EKB Journal Management System, , , 2025, -. doi: 10.21608/zumj.2025.402496.4045
Hanna, A., Elsayed, N., Obaya, A., Mostafa, E., Khalil, N., Mohammed, A. (2025). 'Comparative Study of Intensity Modulated Radiotherapy, Volumetric Modulated Arc Therapy versus Three Dimensional Radiotherapy in High Grade Glioma Patients', EKB Journal Management System, (), pp. -. doi: 10.21608/zumj.2025.402496.4045
Hanna, A., Elsayed, N., Obaya, A., Mostafa, E., Khalil, N., Mohammed, A. Comparative Study of Intensity Modulated Radiotherapy, Volumetric Modulated Arc Therapy versus Three Dimensional Radiotherapy in High Grade Glioma Patients. EKB Journal Management System, 2025; (): -. doi: 10.21608/zumj.2025.402496.4045

Comparative Study of Intensity Modulated Radiotherapy, Volumetric Modulated Arc Therapy versus Three Dimensional Radiotherapy in High Grade Glioma Patients

Zagazig University Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 08 September 2025  XML
Document Type: Original Article
DOI: 10.21608/zumj.2025.402496.4045
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Authors
Amira Hany Hanna email orcid 1; Nehal Gamal Elsayedorcid 2; Ahmed A. Obaya3; Emad Mostafaorcid 4; Nesma Salah Khalil1; Amira Elwan Mohammedorcid 5
1Clinical OncologyDepartment, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3clinical oncology and nuclear medicine department,faculty of medicine,zagazig university
4Clinical Oncology and Nuclear Medicine department, Faculty of Medicine, Zagazig University Zagazig, Egypt.
5Assistant professor of clinical oncology,Zagazig University, Al sharkia
Abstract
Back ground: In contrast to three-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT) improves dose homogeneity, conformity, and target volume coverage while delivering less radiation to normal brain tissue and organs at risk , such as the brainstem, optic nerves, optic chiasm, and brainstem. VMAT is an advanced radiation therapy method that administers radiation continuously while the treatment machine rotates around the patients.

Methods: Planning data from 48 patients with high-grade glioma (HGG) were analyzed. The dose distribution for the CTV, PTV, and OAR was compared across three techniques—3D CRT, IMRT, and VMAT—using Dose Volume Histograms (DVHs)



Results: We found the PTV coverage in terms of V95% was significantly higher in the VMAT and IMRT plans with values of 99.93 ± 0.12 and 99.49± 0.61 respectively compared to 98.23 ± 0.64 for the 3D-CRT plans





Conclusion: the VMAT technique has proven better capability in reducing the radiation exposure to nearby healthy organs .



Key words:3DCRT,IMRT,VMAT and HGG.
Keywords
IMRT; VMAT; 3DCRT; HGG
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