The value of fetal umbilical artery, middle cerebral artery, ductus venosus and umbilical vein Doppler indices as predictors of perinatal outcome among pregnant women with pre-gestational or gestational diabetes. (A prospective cohort study)
El-Demiry, N., Abdulaziz, A., Hefny, A., Saad, H., Abu ElKassem, M., Helmy, N. (2025). The value of fetal umbilical artery, middle cerebral artery, ductus venosus and umbilical vein Doppler indices as predictors of perinatal outcome among pregnant women with pre-gestational or gestational diabetes. (A prospective cohort study). EKB Journal Management System, (), -. doi: 10.21608/ebwhj.2025.421521.1507
Nihal Mostafa El-Demiry; Amani Abdulaziz; Ahmed Shamel Hefny; Hany Saad; Mohamed Abu ElKassem; Nadia Mohamed Helmy. "The value of fetal umbilical artery, middle cerebral artery, ductus venosus and umbilical vein Doppler indices as predictors of perinatal outcome among pregnant women with pre-gestational or gestational diabetes. (A prospective cohort study)". EKB Journal Management System, , , 2025, -. doi: 10.21608/ebwhj.2025.421521.1507
El-Demiry, N., Abdulaziz, A., Hefny, A., Saad, H., Abu ElKassem, M., Helmy, N. (2025). 'The value of fetal umbilical artery, middle cerebral artery, ductus venosus and umbilical vein Doppler indices as predictors of perinatal outcome among pregnant women with pre-gestational or gestational diabetes. (A prospective cohort study)', EKB Journal Management System, (), pp. -. doi: 10.21608/ebwhj.2025.421521.1507
El-Demiry, N., Abdulaziz, A., Hefny, A., Saad, H., Abu ElKassem, M., Helmy, N. The value of fetal umbilical artery, middle cerebral artery, ductus venosus and umbilical vein Doppler indices as predictors of perinatal outcome among pregnant women with pre-gestational or gestational diabetes. (A prospective cohort study). EKB Journal Management System, 2025; (): -. doi: 10.21608/ebwhj.2025.421521.1507

The value of fetal umbilical artery, middle cerebral artery, ductus venosus and umbilical vein Doppler indices as predictors of perinatal outcome among pregnant women with pre-gestational or gestational diabetes. (A prospective cohort study)

Evidence Based Women's Health Journal
Articles in Press, Accepted Manuscript, Available Online from 08 September 2025
Document Type: Original Article
DOI: 10.21608/ebwhj.2025.421521.1507
Authors
Nihal Mostafa El-Demiry* 1; Amani Abdulaziz2; Ahmed Shamel Hefny3; Hany Saad2; Mohamed Abu ElKassem2; Nadia Mohamed Helmy2
1Obstetrics and Gynecology department, Faculty of Medicine, Cairo university, Cairo, Egypt.
2Obstetrics and Gynecology department, Faculty of Medicine - Cairo University, Cairo, Egypt.
3Obstetrics and Gynecology department, Faculty of Medicine, New Giza University, Giza, Egypt
Abstract
Background:The presence of maternal diabetes mellitus during pregnancy has important

consequences for both mother and child.Doppler ultrasound improved perinatal outcomes and reduced maternal and neonatal morbidity.

Objective:Assess the diagnostic accuracy of Doppler sonography in predicting adverse

perinatal outcomes in diabetic pregnant women,focusing on the umbilical artery,fetal middle cerebral artery,ductus venosus,and umbilical vein.

Methodology:Prospective cohort study performed on 140 pregnant women between 34

weeks and 39 weeks,diagnosed with diabetes.UA,MCA,DV and UV Doppler indices were measured. Main outcome was to assess the diagnostic efficacy of the UA and MCA Doppler indices in predicting unfavorable perinatal outcomes.The secondary outcome was to assess the diagnostic efficacy of CPR(MCA/UA PI) ratio, DV Doppler indices, and UV flow waves in predicting unfavorable perinatal outcomes.

Results: Statistically Significant differences were demonstrated between the poor and good

outcome groups regarding all calculated Doppler indices except UV pulsatility(P< 0.001).

UA PI (1.11 ± 0.39 vs. 0.95 ± 0.17, P <0.001), UA RI (0.70 ± 0.17 vs. 0.63 ± 0.07, P <0.001),

MCA PI (1.27 ± 0.20 vs. 1.47±0.18, P 0.001), MCA RI (0.68 ± 0.07 vs. 0.77 ± 0.07,

P<0.001), Cerebroplacental ratio (1.28 ± 0.52 vs. 1.59 ± 0.35, P <0.001) in women with

adverse and favorable perinatal outcome respectively.AUC ROC analysis revealed that UA PI, RI and CPR were the indices of greater discriminant capacity.

Conclusion: UARI, UAPI, MCA PI, CPR, and DV a wave, have proven to be valuable in the prediction of unfavorable perinatal outcomes.CPR less than 1 is an effective predictor of adverse neonatal outcomes.
Keywords
Diabetus - umbilical RI; PI - middle cerebral RI; PI - Ductus venosus doppler - Umbilical vein flow
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