Responses Of Obesity Associated Metabolic Disorders To Supplementation Of Vitamin D In Adult Male Rats. | ||
| ARCADEs of MEDICINE | ||
| Articles in Press, Accepted Manuscript, Available Online from 08 September 2025 | ||
| Document Type: Original Research | ||
| DOI: 10.21608/arcmed.2025.409504.1151 | ||
| Author | ||
| Adel moustafa Hegazy* | ||
| Physiology department Armed Forces College of Medicine, Cairo, Egypt | ||
| Abstract | ||
| Background: Overweight constitutes a major public health concern worldwide, bringing with it serious health sequelae. Inadequate vitamin D concentrations have been associated with heightened vulnerability toward developing obesity. Aim of work: to evaluate the influence of vitamin D enhancement on surplus body mass and corresponding insulin resistance to examine the pathways through which vitamin D influences fat tissue as a strategy for obesity prevention and control alongside related metabolic disorders. Materials and Methods: Thirty rats were randomly distributed among three equivalent cohorts. Control group: Rats provided standard nutrition (lipid composition 4-5%) throughout twelve weeks. Obese group: Rats provided high-lipid nutrition (lipid composition 16-17%) alongside fructose 20% supplemented in drinking water throughout twelve weeks. Vitamin D supplemented obese group: Rats received high-lipid nutrition as cohort II while concurrently administered vitamin D supplementation at 400 IU/kg dosage daily through oral gavage throughout twelve weeks. Every subject received evaluation of body weight (BW), naso-anal measurements and waist circumference (WC). BMI and lee parameters were calculated. Blood specimens were analyzed for glucose, lipid concentrations, insulin, leptin, MDA, Interleukin-6 and tumor necrosis factor-alpha. The indicators of insulin responsiveness and atherogenic ratios were determined. The retroperitoneal fat tissue was examined through histopathological examination. Results and conclusion: vitamin D decreased the waist–circumference gain and had an antioxidant, anti-inflammatory activity, a protective response against dyslipidemia and glycemic disturbances. | ||
| Keywords | ||
| Insulin; Dyslipidemia; T2DM | ||
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