Some Coumarin Scaffolds Incorporated Benzocaine with Antioxidant Activity | ||
| Mansoura Journal of Chemistry | ||
| Volume 68, Issue 3, September 2025, Pages 59-67 PDF (1.18 M) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/mjcc.2025.415808.1023 | ||
| Authors | ||
| Israa Taha; Eman M. Keshk; Abdel-Galil M. Khalil; Ahmed Fekri* | ||
| Chemistry Department, Faculty of Science, Mansoura University, Egypt | ||
| Abstract | ||
| Our bodies are exposed to different pollutants containing harmful radicals that threaten our health. Reactive oxygen species play a critical role in protecting cellular functions. In our study, we introduced coumarin derivatives synthesized through Knoevenagel condensation. Chemical elucidation of tested compounds was accomplished via IR, 1H-NMR, 13C-NMR, and mass spectrometry. We evaluated the antioxidant properties of these compounds using the 1,1-Diphenyl-2-picrylhydrazyl assay. Among them, acetyl coumarin 7 showed the highest activity, with a minimum effective concentration value of 0.174 mg/ml. Antioxidant activity increases as the concentrations of tested compounds increase. Cinnamoyl coumarin 8 displayed moderate antioxidant results, while imino coumarin 6 was less effective in comparison. The most potent analogue, acetyl coumarin 7, exhibited the lowest HOMO-LUMO energy gap level and also possessed low steric hindrance. Some global reactivity descriptors were calculated as chemical potential, hardness, and electronegativity. Thus, these coumarin scaffolds may potentially serve as bio-supplements for antioxidant purposes. | ||
| Keywords | ||
| Antioxidant; Azo dye; Coumarin; Lipinski | ||
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