Histological Study on the Effect of Taurine on Cisplatin Induced Sciatic Nerve Neuropathy in Adult Male Albino Rats. | ||
| Benha Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 11 September 2025 PDF (2.58 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2025.397488.2494 | ||
| Authors | ||
| Shereen M. Mostafa* 1; Maysara Abu El Abbas Salem2; Hamdy A. Mohamed3; Enas Elgendy4 | ||
| 1M.B.B.Ch, Faculty of Medicine, Benha University | ||
| 2Department of Histology and Cell Biology faculty of Medicine - Banha University | ||
| 3Assistant Professor of Histology and Cell Biology, Faculty of Medicine, Benha University | ||
| 4Lecturer of Histology and Cell Biology, Faculty of Medicine, Benha University | ||
| Abstract | ||
| Background: Cisplatin (CIS) is a powerful anti-neoplastic medication, it has adverse effects including peripheral neuropathy. Taurine (Tau) protects the cells by stabilizing membranes, regulating calcium levels, antioxidant and modulating apoptosis and inflammation. Objective: evaluate the protective impact of Tau on peripheral neuropathy caused by CIS. Materials and Methods: 45 healthy adult male albino rats spanning 150 to 250 grams were indiscriminately assigned to four groups. Group I: control group. Group II (CIS group): The animals were administered intraperitoneal (IP) injection of CIS at a dosage of 2.5 mg/kg/day, with treatments biweekly throughout four-weeks duration Group III (CIS+Tau): Four days before to the CIS injection, Tau was administered orally by mouth gavage (250 mg/kg/day). of tau then continued for four weeks. Group IV (Tau group): Tau given orally (250 mg/ kg/ day) daily for four weeks. Sciatic nerve samples were obtained and prepared for light and electron microscopy evaluation. Results: Group II showed disorganized nerve bundle architecture and wide separation of nerve fibers. Nuclei of Schwann cells (SC) were apparently decreased. Small darkly stained pyknotic nuclei and inflammatory cell infiltrate were observed. A statically significant difference in collagen fiber deposition (P <0.01) was observed relative to group I. sciatic nerve by electron microscopy exhibited degenerative changes affecting myelin sheath and axons. Group III exhibited partial improvement in certain histological features and a decrease in collagen fibres content that was statistically significant (P < 0.01) in comparison to Group II. Conclusion: This work concluded that Tau can ameliorate CIS- induced peripheral neuropathy. | ||
| Keywords | ||
| CIS; Sciatic nerve; Peripheral neuropathy; Tau | ||
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