Nanoemulgels: Bridging the Gap between Conventional Emulsions and Modern Nanomedicine | ||
| Octahedron Drug Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 11 September 2025 | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/odr.2025.420776.1058 | ||
| Authors | ||
| Hanin M. Albesh; Hend Diaa Abdullah* | ||
| 23 December street | ||
| Abstract | ||
| The goal of the novel drug delivery technique known as nano-emulgel is to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have several disadvantages, including poor solubility, variable absorption, and limited oral bioavailability. Nano-emulgel is an amalgamated preparation of many systems that aims to overcome these limitations. A special approach that improves stability and permits both immediate and controlled release of the medication is produced by mixing nano-emulsion with gel. Low and high energy techniques were employed to fabricate nanoemulsions. They were characterized through multiple methods including rheological behavior, stability, droplet size, spreadability, pH determination, in vitro drug release, homogeneity, organoleptic tests and phase separation. Because of its safety profile, ease of use, lack of first-pass metabolism and capacity to deliver medications precisely where they are required, nano-emulgel has also drawn greater interest. The preparation, safety profiles and applications of nano-emulgel for topical drug delivery are the main topics of this review. | ||
| Keywords | ||
| Nanoemulsion; Poor solubility; spreadability; and targeted delivery | ||
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