Microneedling Combined with Platelet-rich Plasma for Management of Burn Scars: A Clinical and Histological Study | ||
| SVU-International Journal of Medical Sciences | ||
| Volume 8, Issue 2, July 2025, Pages 461-469 PDF (681.89 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2024.320609.1980 | ||
| Authors | ||
| Maram Ashraf Lotfy* 1; Mahmoud A. Hifny1; Tahany Abbas Elwan2; Ahmed Saada3 | ||
| 1Plastic Surgery Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| 2Histology Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||
| 3General Surgery Department, Faculty of Medicine, South Valley University, Qena, Egypt | ||
| Abstract | ||
| Background: Burn scars pose challenges in plastic surgery with varied treatment outcomes. Microneedling and platelet-rich plasma (PRP) aim to enhance skin regeneration, offering promising results in scar management. Objectives: To evaluate microneedling and PRP's efficacy in managing mature burn scars clinically, and histpathologically Patients and methods: The prospective study at Qena University Hospitals, Egypt, involved 18 outpatient clinic patients with post-burn mature scars. Inclusion criteria included scar presence; exclusions were immunocompromised status, refusal to participate, incomplete data, and concurrent injuries. Patients consented to treatment, photography, and biopsies, with detailed histories and scar assessments using the Vancouver Scar Scale (VSS). Treatment included PRP preparation via autologous blood centrifugation and microneedling with PRP injections over three sessions. Outcome measures included VSS scores, patient satisfaction, and histological analysis after three months. Results: This clinical trial study involved 18 patients; their ages ranged from 4 to 16 years with a mean age of 7.22 ± 3.66 years, of which 72.2% were female. Scald was the prominent burn type in 94.4%. The most common burn site was the left arm (4 patients (22.2%)) followed by the right arm (3 patients (16.7%)) and right flank (2 patients (11.1%)). There was a non-significant difference pre and post-derma rolling with and without PPR, No signficant difference of the histological finding between groups. Conclusion: Combining microneedling and PRP did not significantly improve VSS scores postoperatively. Further research with larger samples and extended follow-up is warranted to explore this treatment's efficacy in burn scar management. | ||
| Keywords | ||
| Microneedling; Platelet-rich plasma; Burn scars; Histological analysis | ||
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