Effects of Acyclovir on the Cerebellar Cortex of Adult Male Albino Rats And The Protective Effect Of Zinc Sulfate (Histological and Immunohistochemical Study) | ||
| SVU-International Journal of Medical Sciences | ||
| Volume 8, Issue 2, July 2025, Pages 470-484 PDF (966.33 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2025.407901.2223 | ||
| Authors | ||
| Asmaa Sabry Bassit* ; Bothina Zakria Elsayed; Ahlam Wagih Mohamed | ||
| Anatomy & Embryology Department, Faculty of Medicine, Sohag University, Sohag, Egypt | ||
| Abstract | ||
| Background: Acyclovir is an antiviral drug. for the treatment of systemic herpes infections and central nervous system infections. Zinc is a vital mineral that found in foods and consumed as a dietary supplement. Objectives: to detect if the acyclovir affected the cerebellar cortical region, and a protective role for zinc sulfate when co-administered with it Material and methods: sixty adult rats were used; they were divided into 4 groups: The control group received distilled water. Group II: received zinc sulfate syrup (30 mg/kg/day) by oral gavage for 2 weeks. Group 3: each rat received (432 mg/Kg) of Acyclovir suspended in distilled water by oral gavage once daily for 2 weeks. Group 4: Animals received acyclovir followed by zinc sulfate syrup. Cerebellar specimens taken and processed for histological and immunohistochemical examination. Results: In the group treated with acyclovir, there were significant decrease in molecular thickness and Purkinje numbers compared to control group where (p value< 0.000),no significant difference between control group and zinc ,zinc &acyclovir treated group(p value >0.5), mild decrease in Purkinje number between control and zinc &acyclovir treated (p<0.012),there increase in area% of BAX,GFAP in acyclovir group (p<0.000), in zinc &acyclovir group (p<0.002) compared to control group. Conclusion: The use of acyclovir can induce significant alterations in the cerebellar cortical area, and zinc sulfate may serve as a potential therapeutic counteract acyclovir-induced neurotoxicity. | ||
| Keywords | ||
| Cerebellum; Zinc sulfate; Acyclovir | ||
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