Comparison between Narrow Band Imaging Technology and Methylene Blue Chromoendoscopy in Early Detection of Barrett’s Esophagus | ||
| SVU-International Journal of Medical Sciences | ||
| Volume 8, Issue 2, July 2025, Pages 495-504 PDF (379.19 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2025.419449.2269 | ||
| Authors | ||
| Amany Ahmed Sorour Albana1; Ehab Abdelaaty1; Amel Sobhy Mahmoud Alsedfy2; Zeinab Madian Elattar Madian Abdelgawad3; Neveen Rashad Mostafa* 3 | ||
| 1Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt | ||
| 2Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, Egypt. | ||
| 3Department of Clinical & Experimental Internal Medicine, Medical Research Institute, Alexandria University, Alexandria, Egypt. | ||
| Abstract | ||
| Background: Gastroesophageal reflux disease (GERD) is a chronic lower esophageal disorder with a variant global prevalence. Barrett's esophagus (BE) represents the replacement of the normal squamous epithelium lining of the lower esophagus by a specialized columnar epithelium and is a forerunner of esophageal adenocarcinoma (EAC). The EAC prevention paradigm relies on endoscopic monitoring of BE to identify dysplastic changes and deliver effective endoscopic treatment. Objectives: are an assessment of the diagnostic effectiveness of narrow-band imaging-targeted (NBI) and methylene blue chromoendoscopy-targeted biopsies (MBCE) using high-resolution upper gastrointestinal endoscopy (HR-UDIE) compared to four-quadrant biopsies, using conventional upper gastrointestinal endoscopy (C-UGIE) as the gold standard for comparison. Patients and methods: Fifty patients were clinically evaluated and underwent C-UGIE using a video endoscopy system, Olympus GIF 240, to obtain four-quadrant biopsies from any salmon-colored mucosa or visible suspicious lesion extending for ≥1 cm proximal to the gastroesophageal junction. Six weeks later, all patients were re-examined using HR-UGIE (EVIS X1), and biopsy taking was performed using either NBI or MBCE. Results: Pathological examinations of the four-quadrant biopsies obtained by the C-UGIE detected variant pathological diagnoses, including BE with different degrees of dysplasia, and three patients had EAC. Pathological diagnoses of biopsies obtained by NBI or chromoendoscopy were comparable (P = 0.939). The diagnostic performance of NBI and MBCE for BE and EAC was comparable and matched with the result of the gold standard method. Conclusion: Both NBI and MBCE can be effectively applied for BE screening in patients with chronic GERD. | ||
| Keywords | ||
| Gastroesophageal reflux disease (GERD); Barrett’s esophagus; Esophageal adenocarcinoma; Narrow-band imaging (NBI); Chromoendoscopy | ||
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