Immunological (Autoantibody) and Physiological Assessment of Lipid Metabolism and Vitamin D3 Levels in Female Patients with Thyroid Disorders | ||
| Journal of Bioscience and Applied Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 13 September 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbaar.2025.374201.1181 | ||
| Authors | ||
| RJ AbdulKhaliq1; AK Ismael2; Sabaa M Farhan* 3; SS Ali4; ZK Alani5 | ||
| 1Department of Pathological Analysis, Applied Science College, University of Fallujah, Al-Anbar, Iraq | ||
| 21Department of Pathological Analysis, Applied Science College, University of Fallujah, Al-Anbar, Iraq | ||
| 3Department of Biotechnology, Applied Science College, University of Fallujah, Al-Anbar, Iraq | ||
| 43Department of Pathological Analysis, College of Medical Technique, Al-Farahidi University, Iraq | ||
| 54College of Pharmacy, Al-Turath University, Baghdad, Iraq | ||
| Abstract | ||
| Objective: The common autoimmune thyroid conditions Hashimoto's thyroiditis (HT) and Graves' disease (GD) cause hypothyroidism and hyperthyroidism, respectively. The purpose of this study was to determine how common thyroid dysfunction is and how it affects vitamin D levels and lipid profiles. Specifically, the research explored how thyroid disorders, particularly autoimmune thyroid diseases, influence lipid metabolism and vitamin D3 concentrations in women. Anti-TPO and anti-TG antibodies were used to validate the existence of autoimmune thyroid disorders. Methods: Thirty healthy controls and sixty women with thyroid problems (30 with hyperthyroidism and 30 with hypothyroidism) participated in a cross-sectional study. Thyroid hormone serum levels (FT3, FT4, and TSH) as well as lipid profiles (total cholesterol (TC), HDL, LDL, and VLDL) were measured and all subjects' vitamin D3 levels were also examined. Results: The results showed that thyroid diseases and thyroid autoimmunity are more common in women. Compared to both hyperthyroid patients and healthy controls, hypothyroid patients had considerably higher levels of total cholesterol, LDL, and triglycerides (TG), as well as lower levels of HDL. On the other hand, the lipid profile of hyperthyroid individuals was closer to that of the control group. Both hypothyroid and hyperthyroid patients had significantly lower vitamin D3 levels than controls. Conclusion: This study emphasizes how thyroid malfunction, especially hypothyroidism, raises the risk of atherosclerosis and cardiovascular illnesses by causing notable alterations in lipid metabolism and vitamin D levels. Women are more likely than men to suffer from these conditions | ||
| Keywords | ||
| Autoimmune thyroid sicknesses, Graves'; disease, Hashimoto'; s thyroiditis, Tri-iodothyronines, Tetra-iodothyronines | ||
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