Immunohistochemical expression of SLP2 in Papillary Thyroid Carcinoma Compared to Follicular adenoma | ||
| Medicine Updates | ||
| Articles in Press, Accepted Manuscript, Available Online from 13 September 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/muj.2025.416986.1255 | ||
| Authors | ||
| Ahmed Ali Elmetwally* 1; Marwa Hosny Khashaba2; Mayada Saad Farrag2; Heba Mohamed Wagih3; Azza Hassan Zidan4 | ||
| 1Pathology Laboratory, Ismailia Teaching Oncology Hospital, Ismailia, Egypt. | ||
| 2Department of Pathology, Faculty of Medicine, Port Said University, Port Said, Egypt. | ||
| 3Department of Pathology, Faculty of Medicine, Suez-Canal University, Ismailia, Egypt. | ||
| 4- Galala University, Suez, Egypt. - Department of Pathology, Faculty of Medicine, Port Said University, Port Said, Egypt. | ||
| Abstract | ||
| Background: Thyroid neoplasms are common worldwide as well as in Egypt. The most common follicular neoplasm is follicular adenoma, and the most common thyroid carcinoma is papillary thyroid carcinoma. Stomatin-Like Protein 2 (SLP2) antibody is expressed in various types of thyroid lesions. Aim: Assessment of immunohistochemical expression of SLP2 in papillary thyroid carcinoma and in follicular adenoma. Also, to assess its expression in PTC with variable demographic and histopathological parameters. Subjects and Methods: The current study is a cross-sectional analytical study, executed in the pathology laboratory of Suez Canal University Hospital over 30 samples, 15 blocks are of PTC samples, and 15 blocks are of follicular adenoma, gathered during the period of January 2019 to January 2020. Results: SLP2 is positively expressed in 86.7% of PTC samples and in 20% of follicular adenoma samples. There is a statistically significant association between positive expression of SLP2 in PTC samples, compared to follicular adenoma samples (p = 0.0007). There is no statistically significant association between SLP2 expression and variable demographic and histopathological parameters in PTC samples. SLP2 has 86.67% sensitivity, 80% specificity, 81.25% positive predictive value, 85.71% negative predictive ratio and 83.33% diagnostic accuracy respectively. . Conclusions: SLP2 is a good diagnostic marker of PTC compared to follicular adenoma with higher intensity and proportion of staining in PTC samples. Keywords: SLP2, PTC, follicular adenoma. | ||
| Keywords | ||
| SLP2; PTC; follicular adenoma | ||
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