TROP2 Immunohistochemical expression in Classic and Infiltrative Follicular Variants of Papillary Thyroid Carcinoma and its Association with Histopathological Parameters | ||
| Medicine Updates | ||
| Articles in Press, Accepted Manuscript, Available Online from 13 September 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/muj.2025.417015.1256 | ||
| Authors | ||
| Ahmed Ali Elmetwally* 1; Marwa Hosny Khashaba2; Mayada Saad Farrag2; Heba Mohamed Wagih3; Azza Hassan Zidan4 | ||
| 1Pathology Laboratory, Ismailia Teaching Oncology Hospital, Ismailia, Egypt. | ||
| 2Department of Pathology, Faculty of Medicine, Port Said University, Port Said, Egypt. | ||
| 3Department of Pathology, Faculty of Medicine, Suez-Canal University, Ismailia, Egypt. | ||
| 4- Galala University, Suez, Egypt. - Department of Pathology, Faculty of Medicine, Port-Said University, Port-Said, Egypt. | ||
| Abstract | ||
| Background: Thyroid tumors are very common in Egyptian population, having 2% incidence and 7.73% prevalence. The most common type of malignant thyroid tumors is papillary thyroid carcinoma (PTC). Trophoblast Cell Surface Antigen 2 (TROP-2) antibody is expressed in various types of thyroid lesions. Aim: To assess immunohistochemical expression of TROP-2 in classic and follicular variants of papillary thyroid carcinoma. Also, to evaluate association of its expression with variable demographic and histopathological parameters. Subjects and Methods: The current study is a cross-sectional analytical study. Thirty-six cases were collected during the period of January 2017 to January 2018. The paraffin blocks are retrieved from archives of pathology laboratory at Suez Canal University Hospital; 18 blocks of classic PTC cases and 18 blocks of follicular variant of PTC (FVPTC). Results: TROP-2 is positively expressed in 94.4% of classic variants of PTC and in 77.78% of infiltrative FVPTC. There is no statistically significant association between classic and FVPTC and the results of expression of TROP-2 (p = 0.337). TROP2 positive expression showed a statistically significant association with higher tumor stage in FVPTC group. The rest of demographic and histopathological parameters have shown no statistically significant association with TROP2 expression in either classic PTC or FVPTC groups. Conclusions: TROP2 shows frequent membranous positivity in both classic and infiltrative follicular variant of PTC with higher levels of positivity in classic variant, within FVPTC group, TROP2 is positively correlated with higher T stage. Keywords: TROP-2, classic variant of PTC, infiltrative FVPTC. | ||
| Keywords | ||
| TROP-2; classic variant of PTC; infiltrative FVPTC | ||
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