Electroretinogram Changes Before and After Intra Vitreal Injection of Ranibizumab for Diabetic Macular Edema | ||
| Egyptian Journal of Ophthalmology | ||
| Volume 5, Issue 3, September 2025, Pages 100-112 PDF (1021.08 K) | ||
| Document Type: Original Articles | ||
| DOI: 10.21608/ejomos.2024.320886.1145 | ||
| Authors | ||
| Ahmed Rezk* 1; Taher Gamal El-Deen1; Mona Abd-el kader Ramadan1; Amr Mohammed Abdelkader2 | ||
| 1Mansoura Ophthalmic Center, Mansoura University | ||
| 2Mansoura university Ophthalmic center - EL Gomhoria st. Mansoura university | ||
| Abstract | ||
| Objective: To evaluate the role of multifocal Electroretinogram (mf-ERG) in the follow up of DME after intravitreal Anti-VEGFs (Ranibizumab). Methods: This prospective, case series, interventional, analytic study was held on 25 eyes of 25 patients with DME and had intravitreal injection (IVI) of ranibizumab. Pre-operative investigations included assessment of visual acuity and BVCA and slit lamb biomiocroscopy. Imaging included OCT and electroretinography (ERG) were also conducted. All cases were followed up after one week, one month, two months and three months from each injection by assessment of visual acuity (VA), best corrected visual acuity (BCVA), slit lamb biomiocroscopy (SLB), OCT and ERG. Results: There was statistically significant change in macular thickness and BCVA after treatment in comparison with pre-treatment. There was statistically significant difference in amplitude p1 in (ring 1, ring 2 and ring 3) between baseline pre and post-treatment. There was statistically significant difference in Implicit time PET P1 in (ring 1 ring 2 and ring 3) between baseline before and after treatment. There was statistically significant correlation between delta amplitude and delta implicit time and (macular thickness, HBA1C and BCVA) in (Ring 1, Ring 2 and Ring 3) among studied cases (P<0.05). Conclusion: This study added evidence for the contribution of anti-VEGFs, particularly Ranibizumab, in improving macular function in cases with DME. Postsurgical improvement in VA was accompanied by diminished macular thickness and improved P1 amplitude in the central ring measured by mf-ERG. | ||
| Keywords | ||
| Diabetic macular edema; Ranibizumab; VEGF; OCT | ||
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